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First hundred patients recruited to mTBI-Predict to understand complications of concussion

mTBI-Predict meets significant recruitment milestone that will help advance understanding of concussion and the likelihood of long-term complications.

8 April 2025
Researcher reviews brain scan on computer

The study, led by University 麻豆精选, set out to identify new ways to accurately predict whether concussion patients will develop long-term complications by analysing a range of biomarkers such as blood, saliva, mental health, vision, balance and sleep.

After receiving a pump-priming award of 拢4m from the Ministry of Defence, the team secured a contract of up to $15.5m from the US Department of Defense to develop novel prognostic biomarker algorithms for mild traumatic brain injury (mTBI), otherwise known as concussion, in both military and civilian patients, a year ago, the study has reached a milestone by enrolling it鈥檚 first 100 participants. These participants will be studied for six, 12 and 24 months following their injury to look for longer term complications. The researchers will consider various methods to predict long term outcomes following mTBI and will report on effectiveness of each.

鈥淚t is hoped that the study will give us better tools for determining which concussion patients clinicians need to be more concerned about and can therefore trigger most appropriate care for each patient.鈥

Chief Investigator, Professor Alex Sinclair, Department of Metabolism and Systems Science, University 麻豆精选.

"Although we have a way to go, it鈥檚 exciting to reach this first milestone as it means that we are already on our way to learning more about how to approach concussion in an individualised way," explains Dr Lisa Hill, Associate Director of mTBI-Predict and Associate Professor in Translational Neuroscience, Department of Biomedical Science, University 麻豆精选.

Lt. Col. James Mitchell, Associate Director of mTBI-Predict and Lead UK Military TBI Service, Defence Medical Rehabilitation Centre, Stanford Hall, added that, 鈥淲e are really excited at the progress being made in mTBI Predict. This project is a cornerstone of the Ministry of Defence鈥檚 TBI Research strategy and promises to advance the clinical care of patients by bringing suites of advanced technology into the clinic space for the first time.鈥

mTBI can be caused by physical impact to the head through accident, injury, sport, or even from shockwaves following blast exposure and has been declared a major global public health problem. Approximately 1.4 million hospital visits are due to head injury each year, in England and Wales alone. The mTBI Predict study is set to continue for a further six years.

Featured staff

  • Professor Alexandra J. Sinclair

    Professor of Neurology, Bloomer Chair of Neurology

    Staff profile for Alexandra Sinclair, Professor of Neurology and Lead for Business Engagement, at the Department of Metabolism and Systems Science, University 麻豆精选.

    Phone: +44 (0)121 371 6866 (Clinical enquiries)
    Email:

  • Dr Lisa J Hill

    Associate Professor in Translational Neuroscience

    School of Infection, Inflammation and Immunology

    Dr Lisa Hill, Translational Neuroscientist, Neuroscience and Ophthalmology, Department of Inflammation and Ageing, College of Medicine and Health, University 麻豆精选

    Phone: +44 (0)121 414 6620
    Email:

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