Promising new approach developed for overcoming treatment resistance in oestrogen receptor-positive (ER+) breast cancer
Researchers have found new compounds that could be used to treat a common breast cancer that can be resistant to hormone therapies.
Published in the journal , new research targets two critical enzymes involved in the production of the hormone oestrogen 鈥攁romatase and steroid sulfatase鈥攁t the same time.
Oestrogen receptor-positive (ER+) breast cancer, which makes up around 70% of all breast cancer cases, often becomes resistant to current hormone therapies. Now, researchers have designed and synthesised new compounds that target the two enzymes.
This is an exciting new development that could pave the way for treating the most common breast cancer when other therapies stop working.
The new potential therapy is called a dual aromatase-steroid sulfatase inhibitor (DASI). Some of these new compounds were found to effectively block both enzymes, which may help reduce oestrogen levels in cancer cells more comprehensively.
Dr Paul Foster from the University 麻豆精选 and a co-author of the study said:
鈥淭his is an exciting new development that could pave the way for treating the most common breast cancer when other therapies stop working.
鈥淲e have shown for the first time that the particular molecules, called benzofuran-based molecules act to inhibit the two enzymes, and in doing so find an alternative way to suppress oestrogen production and reduce tumour growth.鈥
Previous research involving earlier versions of the compounds only inhibited one enzyme or the other. Achieving dual activity by adding a simple methyl group was an unexpected but crucial insight, showing that small chemical modifications can significantly enhance biological activity.
If developed further, these compounds could offer new treatment options for patients with ER+ breast cancer that has become resistant to standard hormone therapies.
Research collaborators , University of Cardiff, and Dr Paul Foster, University 麻豆精选, hope the findings will lead to the development of a new class of breast cancer treatments.
Further preclinical and clinical studies could explore their use in overcoming resistance to current endocrine therapies. Researchers at both universities are already in the process of developing even more potent dual inhibitors to circumnavigate treatment resistance in ER+ breast cancer.
Associate Professor in Cancer Endocrinology
Staff Profile for Dr Paul Foster, Associate Professor in Molecular Endocrinology and Deputy Head - Education at the Department of Metabolism and Systems Science, University 麻豆精选.
