Shown here are some of the recent outstanding publications which highlight significant advances made by researchers in our department.
Molecular Cell Oct 10:S1097-2765(23)00761-X (2023). Cvetkovic MA, P Passaretti, A Butryn, A Reynolds-Winczura, G Kingsley, A Skagia, . . .G Stewart, A Gambus and A Costa.
Cell Reports 42:112372 (2023). Sun C, E Seranova, MA Cohen, M Chipara, J Roberts, D Astuti, . . . VI Korolchuk and S Sarkar.
18:1090-1106 (2023). Zatyka M, TR Rosenstock, C Sun, AM Palhegyi, GW Hughes, S Lara-Reyna, . . . T Barret and S Sarkar. Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome.
Nature Medicine doi.org/10.1038/s41591-023-02414-4 (2023). Barnes E, CS Goodyear, M Willicombe, C Gaskell, . . . . . . Thomas D, Kearns P, Kirkham A, McInnes IB, and The OCTAVE Collaborative Group. .
Cell Reports 42:112571 (2023). Mahony CB, L Copper, P Vrljicak, B Noyvert, C Constantinidou, S Browne, . . . R Monteiro. . doi: https://doi.org/10.1016/j.celrep.2023.112571
Lancet Oncology (online) (2023). H Mehanna, M Taberna, C von Buchwald, S Tous, J Brooks, M Mena, . . . The HNCIG-EPIC group. . doi: https://doi.org/10.1016/S1470-2045(23)00013-X.
Blood 2022019138 (2023). Clarke ML, RB Lemma, DS Walton, G Volpe, B Noyvert, OS Gabrielsen and J Frampton. . doi: 10.1182/blood.2022019138
Nat Commun 14:267 (2023). Edginton-White B, A Maytum, SG Kellaway, DK Goode, P Keane, I Pagnuco, . . . C Bonifer. .
Dev Cell 58:155-170 e158 (2023). Hadzhiev Y, L Wheatley, L Cooper, F Ansaloni, C Whalley, Z Chen, . . . A Beggs, F Muller. .
Cell Reports 42:112207 (2023). Molostvov G, M Gachechiladze, AM Shaaban, S Hayward, I Dean, IHK Dias, . . . F Berditchevski. .
Developmental Cell 57:2584-2598 e2511 (2022). Kataura T, L Sedlackova, EG Otten, R Kumari, D Shapira, F Scialo, . . .S Sarkar and VI Korolchuk. .
Sci Adv 8:eabq2611 (2022). Taylor MJ, AM Thompson, S Alhajlah, RI Tuxworth and Z Ahmed. .
Clin Transl Med 12:e962 (2022). Ahmed Z and RI Tuxworth. .
Blood doi: 10.1182/blood.2021015036 (2022). Tirtakusuma R, K Szoltysek, P Milne, V Grinev, A Ptasinska, PS Chin, . . . C Bonifer, O Heidenreich, S Bomken. .
Elife 11 (2022). Vilaplana-Lopera N, V Cuminetti, R Almaghrabi, G Papatzikas, AK Rout, M Jeeves, . . . P Garcia. .
Nat Genet 54:1037-1050 (2022). Baranasic D, M Hortenhuber, PJ Balwierz, T Zehnder, AK Mukarram, C Nepal, . . . F Muller. .
J Clin Invest 132 (2022). Abu-Libdeh B, SS Jhujh, S Dhar, JA Sommers, A Datta, GM Longo, . . . GS Stewart. .
Mol Cell 82:1924-1939 e1910 (2022). Bayley R, V Borel, RJ Moss, E Sweatman, P Ruis, A Ormrod, . . . MR Higgs. .
Lancet 398:1427-1435 (2021). Karwath A, KV Bunting, SK Gill, O Tica, S Pendleton, F Aziz, . . . GV Ghoutos, D Kotecha,
Front Immunol 12:642807 (2021). Bevington SL, R Fiancette, DW Gajdasik, P Keane, JK Soley, CM Willis, . . . PN Cockerill. .
EMBO Rep 22:e51120 (2021). Blakemore D, N Vilaplana-Lopera, R Almaghrabi, E Gonzalez, M Moya, C Ward, . . . P Garcia. .
Nat Comm 12: 6313 (2021). M-P Sanchez-Bailon M-P, S-Y Choi, ER Dufficy, K Sharma, GS McNee, … CC Davies. .
PNAS (Proceedings of the National Academy of Sciences of the United States of America) 118 (39) (2021) Regina Andrijes, Rahul K. Hejmadi, Matthew Pugh, Sundaresan Rajesh, Vera Novitskaya, Maha Ibrahim, Michael Overduin, Chris Tselepis, Gary W. Middleton, Balázs Győrffy, Andrew D. Beggs, and Fedor Berditchevski .
Lancet 397:387-397 (2021). Bhangu A and Global Surgery Collaborative and National Institute for Health Research Global Health Research Unit on Global Surgery. .
Cell Reports 35:109010 (2021). Potluri S, SA Assi, PS Chin, DJL Coleman, A Pickin, S Moriya, . . . PN Cockerill, C Bonifer. .
Cell Reports 34:108759 (2021). Wang J, P Rojas, J Mao, M Muste Sadurni, O Garnier, S Xiao, . . . MR Higgs, P Garcia, M Saponaro. .
Lancet 395:1268-1277 (2020). Birtle A, M Johnson, J Chester, R Jones, D Dolling, RT Bryan, . . . E Hall.
J Clin Oncol:JCO2001933 (2020).Glasbey JC, A Bhangu and COVID Surg Collaborative. .
EMBO J:e105220 (2020). Bevington SL, P Keane, JK Soley, S Tauch, DW Gajdasik, R Fiancette, . . . PN Cockerill.
Lancet 395:417-426 (2020). Bhangu A and Reinforcement of Closure of Stoma Site (ROCSS) Collaborative and West Midlands Research Collaborative. .
Cell Rep 31:107748 (2020). Bevington SL, STH Ng, GJ Britton, P Keane, DC Wraith and PN Cockerill. . Find out more: Birmingham scientists 're-train' immune system to prevent attack of healthy cells in new UK study into autoimmune diseases.
Lancet Child Adolesc Health 4:271-280 (2020). Bhangu A and Rift Study Group on behalf of the West Midlands Research Collaborative. . Find out more: Urgent improvements needed in the care of children with suspected appendicitis - study
Lancet 396:27-38 (2020). Bhangu A and COVIDSurg Collaborative. . Find out more: COVID-19 patients who undergo surgery are at increased risk of postoperative death – global study
Cancer Cell 38:306-307 (2020). Lee LYW, T Hill, O Topping, M Tilby, M Baker, J Greig, . . . UKBCCC- Project. .
Lancet Oncol 21:1309-1316 (2020). Lee LYW, JB Cazier, T Starkey, SEW Briggs, R Arnold, V Bisht, . . . UKCCMP Team..
J Clin Oncol 38:2552-2557 (2020). Mehanna H, D Rischin, SJ Wong, V Gregoire, R Ferris, J Waldron, . . . S Porceddu. . Find out more online.
Nature 583:807-812 (2020). Middleton G, P Fletcher, S Popat, J Savage, Y Summers, A Greystoke, . . . L Billingham. . Find out more: Flagship Cancer Research UK precision medicine trial highlights the need for a new approach in treating genomically complicated cancers
Cell Rep 31:107691 (2020). Nafria M, P Keane, ES Ng, EG Stanley, AG Elefanty and C Bonifer. Expression of RUNX1-ETO .
Nat Genet 51:151-162 (2019). Assi SA, MR Imperato, DJL Coleman, A Pickin, S Potluri, A Ptasinska, . . . C Bonifer. . Find out more: Research brings personalised medicine to treat leukaemia one step closer
Nat Commun 10:3577 (2019). Bonkhofer F, R Rispoli, P Pinheiro, M Krecsmarik, J Schneider-Swales, IHC Tsang, . . . R Monteiro, T Peterkin, R Patient..
Nature 571:521-527 (2019). Daza-Martin M, K Starowicz, M Jamshad, S Tye, GE Ronson, HL MacKay, . . . JR Morris. .
Genes Dev 33:333-347 (2019). Garvin AJ, AK Walker, RM Densham, AS Chauhan, HR Stone, HL Mackay, . . . JR Morris. .
PLoS Comput Biol 15:e1006596 (2019). Gendoo DMA, RE Denroche, A Zhang, N Radulovich, GH Jang, M Lemire, . . . B Haibe-Kains. .
Nat Commun 10:691 (2019). Hadzhiev Y, HK Qureshi, L Wheatley, L Cooper, A Jasiulewicz, H Van Nguyen, . . . F Muller.
Cell Rep 28:3022-3031 e3027 (2019). Ptasinska A, A Pickin, SA Assi, PS Chin, L Ames, R Avellino, . . . C Bonifer. .
Ann Oncol 30:456-463 (2019). Spiteri I, G Caravagna, GD Cresswell, A Vatsiou, D Nichol, A Acar, . . . C Watts, A Sottoriva. .
N Engl J Med 381:637-646 (2019). Tamborlane WV, M Barrientos-Perez, U Fainberg, H Frimer-Larsen, M Hafez, PM Hale, . . . T Barrett. Ellipse Trial. .
Cell Rep 25:2061-2069 e2064 (2018). Bowry A, AL Piberger, P Rojas, M Saponaro and E Petermann. .
Cancer Cell 34:674-689 e678 (2018). de Boer B, J Prick, MG Pruis, P Keane, MR Imperato, J Jaques, . . .C Bonifer, JJ Schuringa. .
Nat Commun 9:2704 (2018). Gauvrit S, A Villasenor, B Strilic, P Kitchen, MM Collins, R Marin-Juez, . . . PS Jayaraman, DYR Stainier. .
Mol Cell 71:25-41 e26 (2018). Higgs MR, K Sato, JJ Reynolds, S Begum, R Bayley, A Goula, . . . GS Stewart. .
Cancer Cell 34:626-642 e628 (2018). Martinez-Soria N, L McKenzie, J Draper, A Ptasinska, H Issa, S Potluri, . . . C Bonifer, O Heidenreich. .
PLoS Comput Biol 14:e1006258 (2018). Moradigaravand D, M Palm, A Farewell, V Mustonen, J Warringer and L Parts. .
Nat Commun 9:746 (2018). Ronson GE, AL Piberger, MR Higgs, AL Olsen, GS Stewart, PJ McHugh, . . . ND Lakin. .
Nat Commun 9:229 (2018). Uckelmann M, RM Densham, R Baas, HHK Winterwerp, A Fish, TK Sixma and JR Morris. .
Cell Rep 24:1496-1511 e1498 (2018). Ward C, G Volpe, P Cauchy, A Ptasinska, R Almaghrabi, D Blakemore, . . . P Garcia. .
Nature 559:285-289 (2018). Zimmermann M, O Murina, MAM Reijns, A Agathanggelou, R Challis, Z Tarnauskaite, . . . T Stankovic, AP Jackson, D Durocher. .
Cell Rep 21:3498-3513 (2017). Chiang K, AE Zielinska, AM Shaaban, MP Sanchez-Bailon, J Jarrold, TL Clarke, . . . CC Davies. .
Mol Cell 65:900-916 e907 (2017). Clarke TL, MP Sanchez-Bailon, K Chiang, JJ Reynolds, J Herrero-Ruiz, TM Bandeiras, . . . CC Davies. .
Cell Rep 19:1654-1668 (2017). Loke J, SA Assi, MR Imperato, A Ptasinska, P Cauchy, Y Grabovska, . . . C Bonifer. .
Nat Genet 49:537-549 (2017). Reynolds JJ, LS Bicknell, P Carroll, MR Higgs, R Shaheen, JE Murray, . . . GS Stewart. .
Nat Cell Biol 19:468-479 (2017). Sonneville R, SP Moreno, A Knebel, C Johnson, CJ Hastie, A Gartner, . . . A Gambus, K Labib. .
Cell 168:843-855 e813 (2017). Williamson L, M Saponaro, S Boeing, P East, R Mitter, T Kantidakis, . . . JQ Svejstrup. UV .
Cancer Cell 30:578-594 (2016). Bardella C, O Al-Dalahmah, D Krell, P Brazauskas, K Al-Qahtani, M Tomkova, . . . I Tomlinson. .
EMBO J 35:515-535 (2016). Bevington SL, P Cauchy, J Piper, E Bertrand, N Lalli, RC Jarvis, . . . PN Cockerill. .
PLoS Genet 12:e1005945 (2016). Byrd PJ, GS Stewart, A Smith, C Eaton, AJ Taylor, C Guy, . . . AM Taylor. A.
Nat Struct Mol Biol 23:647-655 (2016). Densham RM, AJ Garvin, HR Stone, J Strachan, RA Baldock, M Daza-Martin, . . . JR Morris. .
Dev Cell 36:572-587 (2016). Goode DK, N Obier, MS Vijayabaskar, ALM Lie, AJ Lilly, R Hannah, . . . C Bonifer. .
Nat Genet 48:36-43 (2016). Harley ME, O Murina, A Leitch, MR Higgs, LS Bicknell, G Yigit, . . . GS Stewart, AP Jackson. .
Genes Dev 30:408-420 (2016). Kantidakis T, M Saponaro, R Mitter, S Horswell, A Kranz, S Boeing, . . . JQ Svejstrup. .
Nat Commun 7:13087 (2016). Kotsantis P, LM Silva, S Irmscher, RM Jones, L Folkes, N Gromak and E Petermann. .
N Engl J Med 374:1444-1454 (2016). Mehanna H, WL Wong, CC McConkey, JK Rahman, M Robinson, AG Hartley, . . . P-NTM Group. .
Dev Cell 38:358-370 (2016). Monteiro R, P Pinheiro, N Joseph, T Peterkin, J Koth, E Repapi, . . . R Patient. .
Cell Rep 12:821-836 (2015). Cauchy P, SR James, J Zacarias-Cabeza, A Ptasinska, MR Imperato, SA Assi, . . . PN Cockerill. .
Mol Cell 59:462-477 (2015). Higgs MR, JJ Reynolds, A Winczura, AN Blackford, V Borel, ES Miller, . . . GS Stewart. .
Lancet 386:249-257 (2015). Kehoe S, J Hook, M Nankivell, GC Jayson, H Kitchener, T Lopes, . . . AM Swart..
Nat Commun 6:7203 (2015). Regha K, SA Assi, O Tsoulaki, J Gilmour, G Lacaud and C Bonifer. .
Nat Commun 5:3756 (2014). Cazier JB, SR Rao, CM McLean, AK Walker, BJ Wright, EE Jaeger, . . . FC Hamdy. .
Mol Cell 53:645-654 (2014). Feng T, A Yamamoto, SE Wilkins, E Sokolova, LA Yates, M Munzel, . . . ML Coleman. .
Nature 507:381-385 (2014). Haberle V, N Li, Y Hadzhiev, C Plessy, C Previti, C Nepal, . . . F Muller, B Lenhard. .
Science 346:477-481 (2014). Moreno SP, R Bailey, N Campion, S Herron and A Gambus..
Cell reports 8:1974-1988 (2014). Ptasinska A, SA Assi, N Martinez-Soria, MR Imperato, J Piper, P Cauchy, . . . C Bonifer. .
Cell 157:1037-1049 (2014). Saponaro M, T Kantidakis, R Mitter, GP Kelly, M Heron, H Williams, . . . JQ Svejstrup. .
EMBO J 32:1556-1567 (2013). Davies CC, A Chakraborty, ME Diefenbacher, M Skehel and A Behrens. .
EMBO Rep 14:975-983 (2013). Garvin AJ, RM Densham, SA Blair-Reid, KM Pratt, HR Stone, D Weekes, . . . JR Morris. .
Genome Res 23:1938-1950 (2013). Nepal C, Y Hadzhiev, C Previti, V Haberle, N Li, H Takahashi, . . . F Muller. .
Nat Genet 45:136-144 (2013). Palles C, JB Cazier, KM Howarth, E Domingo, AM Jones, P Broderick, . . . I Tomlinson. .
Cell Rep 5:1302-1315 (2013). Sarkar S, B Carroll, Y Buganim, D Maetzel, AH Ng, JP Cassady, . . . R Jaenisch. .
J Clin Oncol 30:4477-4484 (2012). Bartlett JM, KJ Bloom, T Piper, TJ Lawton, CJ van de Velde, DT Ross, . . . D Rea. .
EMBO J 31:3918-3934 (2012). Butler LR, RM Densham, J Jia, AJ Garvin, HR Stone, V Shah, . . . JR Morris. .
Lancet Oncol 13:1152-1160 (2012). D Morton and Foxtrot Collaborative G..
Nat Chem Biol 8:960-962 (2012). Ge W, A Wolf, T Feng, CH Ho, R Sekirnik, A Zayer, . . . ML Coleman, CJ Schofield. .
EMBO J 31:4318-4333 (2012). Lichtinger M, R Ingram, R Hannah, D Muller, D Clarke, SA Assi, . . . C Bonifer. .
Mol Cell 45:505-516 (2012). Polo SE, AN Blackford, JR Chapman, L Baskcomb, S Gravel, A Rusch, . . . GS Stewart, RJ Grand, SP Jackson. .
Cell Rep 2:270-282 (2012). Radulescu S, MJ Brookes, P Salgueiro, RA Ridgway, E McGhee, K Anderson, . . . C Tselepis, OJ Sansom. .
J Clin Oncol 30:4524-4532 (2012). Skowronska A, A Parker, G Ahmed, C Oldreive, Z Davis, S Richards, . . . T Stankovic. .