Immune Regulation
The Immune Regulation theme provides new insight into mechanisms that control immune system development and function.
Basic Science Lead
Professor Graham Anderson
Professor of Experimental Immunology
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Clinical Lead
Professor Parth Narendran
Professor of Diabetes Medicine
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Knowledge is gained through spatial, temporal and single cell analysis of immune cells using in vivo models, which is then used to design new approaches for the prevention and treatment of human diseases
- Define key genes, proteins and cells in the innate and adaptive immune systems that control differentiation, homeostasis and regulation of the immune response
- Understand immunity to pathogens and how this can be used to improve vaccination strategies
- Define the pathogenesis of immunological diseases ranging from autoimmunity to transplant rejection and how to manipulate the immune system through immunotherapy
Immune Regulation Principal Investigators
Principal Investigator | Research Interest |
Professor Graham Anderson |
T-cell biology, Thymus and T-cell development, T-cell Tolerance and Immunity. |
Professor Alex Richter |
Emerging field of secondary immunodeficiency. |
Professor Adam Cunningham |
How immune responses develop to vaccines and infection and how they impact on host immune homeostasis. |
Dr Nick Jones |
Transplant immunology, regulatory T-cells, memory T-cells, invariant NKT cells, rejection, tolerance. |
Dr William Jenkinson |
Investigation of mechanisms controlling T-cell development and central tolerance. |
Dr Sarah Dimeloe |
Metabolism of immune cells and how this underpins their role in health and disease. |
Dr David Bending |
Cellular and molecular mechanisms that control T-cell differentiation, function and regulation. |
Dr Rebecca A Drummond |
How organ-specific immune responses develop by studying the behaviour of tissue-resident myeloid cells. |
Professor Sylvie Freeman |
Predicting treatment resistance in acute myeloid leukemia and myelodysplasia principally by monitoring residual disease (MRD). |
Professor Parth Narendran |
Understanding the autoimmune destruction of insulin secreting beta cells that lead to type 1 diabetes. |
Professor Dylan Owen |
Statistical methods for fluorescence microscopy image analysis, the nanoscale architecture of the T cell immunological synapse, protein spatio-temporal organisation in health and autoimmune disease. |
Professor Matt O'Shea |
Tuberculosis, helminths, B cells, antibodies, T cells, generation and maintenance of adaptive responses, vaccination, immune homeostasis, immune modulation. |
Dr Sally Clayton |
Understanding how mitochondrial and metabolic regulation influence the function of immune cells during health and disease. |
Professor Ivan Wall |
Exosomes and extracellular vesicles, cultivated meat and cellular agriculture, stem cell scale up and analytics, MSC activation and functional enhancement. |
Professor Mamidipudi Thirumala Krishna |
Special clinical and research interest in allergic diseases. |
Professor David Wraith |
T cell biology and the role of T lymphocytes in protection from infection and in autoimmunity. |