Professor Dirk-Peter Herten

Dirk-Peter Herten

Department of Cardiovascular Sciences
School of Chemistry
Chair in Cell Biology of Membrane Proteins

Contact details

Email
d.herten@bham.ac.uk
Address
Cardiovascular Sciences & School of Chemistry
College of Medicine and Health
Medical School
University 麻豆精选
Edgbaston
B15 2TT

Dirk-Peter Herten is a Chair in Cell Biology of Membrane Proteins at the University 麻豆精选 shared by Cardiovascular Sciences and the School of Chemistry with his labs located in the Institute of Biomedical Research (IBR).

Dirk’s interdisciplinary research spans from microscopy techniques over switchable fluorescent probes to biological applications, like T-cell signalling in the context of inflammation. He has specialized in single-molecule microscopy enabling quantitative studies of the composition and dynamics of cellular structures and enzymatic reactions in living cells.

ORCID ID:

Researcher ID:

Qualifications

  • Venia legendi in Physical Chemistry 2008
  • PhD in Physical Chemistry 2000
  • Diploma in Chemistry, Heidelberg University 1996

Biography

Dirk graduated from the Heidelberg Department of Physical Chemistry in 2000 after studying Chemistry at the Heidelberg University, Germany.

After collecting experiences in industry at ATTO-TEC GmbH, Germany he returned to academia in 2002 by specializing in single-molecule spectroscopy at Heidelberg University where he was awarded the venia legendi in Physical Chemistry in 2008. In 2015 he became University Professor in Single-Molecule Spectroscopy at Heidelberg University until accepting a Chair in Cell Biology of Membrane Proteins at the University 麻豆精选 in 2019.

Research

Dirk researches tools to enable quantitative studies of the composition and dynamics of cellular structures and enzymatic reactions in living cells. This highly interdisciplinary research will improve our general understanding of intracellular functions and cellular responses to external stimuli in the context of various diseases by bridging biochemistry and cell biology. The design of fluorescent probes for live-cell single-molecule studies has potential for biomedical research and diagnostic applications.

Dirk is currently active in three areas in single-molecule research: single photon based molecular counting, switchable fluorescent probes for advanced fluorescence microscopy, e.g. super-resolution in living cells, and single-molecule studies of chemical reaction pathways.

Publications

Recent publications

Article

Panconi, L, Euchner, J, Tashev, SA, Makarova, M, Herten, D-P, Owen, DM & Nieves, DJ 2024, '', Nature Communications, vol. 15, no. 1, 9641.

Asenov Tashev, S, Euchner, J, Yserentant, K, H盲nselmann, S, Hild, F, Chmielewicz, W, Hummert, J, Schw枚rer, F, Tsopoulidis, N, Germer, S, Sa脽mannshausen, Z, Fackler, OT, Klingm眉ller, U & Herten, D 2024, '', Nature Methods.

Clark, JC, Martin, EM, Mor谩n, LA, Di, Y, Wang, X, Zuidscherwoude, M, Brown, HC, Kavanagh, DM, Hummert, J, Eble, JA, Nieswandt, B, Stegner, D, Pollitt, AY, Herten, D, Tomlinson, MG, Garc铆a, A & Watson, SP 2023, '', Communications Biology, vol. 6, no. 1, 376.

Hild, F, Werther, P, Yserentant, K, Wombacher, R & Herten, D-P 2022, '', Biophysical Reports, vol. 2, no. 4, 100084.

Muzzopappa, F, Hummert, J, Anfossi, M, Tashev, S, Herten, D & Erdel, F 2022, '', Nature Communications, vol. 13, no. 1, 7787.

Ziegler, MJ, Yserentant, K, Dunsing, V, Middel, V, Gralak, AJ, Pakari, K, Bargstedt, J, Kern, C, Petrich, A, Chiantia, S, Str盲hle, U, Herten, D-P & Wombacher, R 2022, '', Nature Chemical Biology, vol. 18, no. 1, pp. 64-69.

Werther, P, Yserentant, K, Braun, F, Gru脽mayer, K, Navikas, V, Yu, M, Zhang, Z, Ziegler, MJ, Mayer, C, Gralak, AJ, Busch, M, Chi, W, Rominger, F, Radenovic, A, Liu, X, Lemke, EA, Buckup, T, Herten, DP & Wombacher, R 2021, '', ACS Central Science, vol. 7, no. 9, pp. 1561鈥�1571.

Navikas, V, Leitao, SM, Grussmayer, KS, Descloux, A, Drake, B, Yserentant, K, Werther, P, Herten, D-P, Wombacher, R, Radenovic, A & Fantner, GE 2021, '', Nature Communications, vol. 12, no. 1, 4565, pp. 4565.

Clark, J, Neagoe, RAI, Zuidscherwoude, M, Kavanagh, D, Slater, A, Martin, E, Soave, M, Stegner, D, Nieswandt, B, Poulter, N, Hummert, J, Herten, D-P, Tomlinson, M, Hill, SJ & Watson, S 2021, '', Thrombosis and Haemostasis, vol. 2021, no. 00, pp. 1-26.

Hummert, J, Yserentant, K, Fink, T, Euchner, J, Ho, YX, Tashev, SA & Herten, D-P 2021, '', Molecular Biology of the Cell, vol. 32, no. 21, pp. ar35.

Wiegand, T, Fratini, M, Frey, F, Yserentant, K, Liu, Y, Weber, E, Galior, K, Ohmes, J, Braun, F, Herten, D-P, Boulant, S, Schwarz, US, Salaita, K, Cavalcanti-adam, EA & Spatz, JP 2020, '', Nature Communications, vol. 11, no. 1, 32.

Sedlmeier, G, Al-Rawi, V, Buchert, J, Yserentant, K, Rothley, M, Steshina, A, Gr盲脽le, S, Wu, R-L, Hurrle, T, Richer, W, Decraene, C, Thiele, W, Utikal, J, Abuillan, W, Tanaka, M, Herten, D-P, Hill, CS, Garvalov, BK, Jung, N, Br盲se, S & Sleeman, JP 2020, '', Advanced Therapeutics.

Werther, P, Yserentant, K, Braun , F, Kaltwasser, N, Popp , C, Baalmann , M, Herten, D-P & Wombacher, R 2020, '', Angewandte Chemie - International Edition, vol. 59, no. 2, pp. 804-810.

Preprint

Navikas, V, Leitao, SM, Grussmayer, KS, Descloux, A, Drake, B, Yserentant, K, Werther, P, Herten, D-P, Wombacher, R, Radenovic, A & Fantner, GE 2020 ''.

Review article

Hummert, J, Tashev, SA & Herten, D-P 2021, '', The International Journal of Biochemistry & Cell Biology, vol. 135, 105978.