Professor Neil Morgan BSc, PhD

Professor Neil Morgan

Department of Cardiovascular Sciences
Professor of Cardiovascular Genetics

Contact details

Email
n.v.morgan@bham.ac.uk
Twitter
Address
Cardiovascular Sciences
College of Medicine and Health
University 麻豆精选
Edgbaston
Birmingham
B15 2TT
UK
Department of Cardiovascular Sciences Research Theme: Thrombosis and Haemostasis

Neil Morgan is a Professor of Cardiovascular Genetics within Cardiovascular Sciences.

He has published over 130 research papers in high impact scientific journals in the field of human genetics and has an H-index of 56, with 14,000 citations. His current research primarily involves the identification and characterisation of novel genes for inherited diseases in the haematopoietic system and haemostasis.

Qualifications

  • PhD in Molecular Genetics 2005
  • BSc (Hons) Applied Biochemistry 1994

Biography

Neil Morgan qualified with a BSc (Hons) in Applied Biochemistry from Liverpool John Moores University in 1994. His first post was as Research Assistant at Guy’s Hospital until 2000 followed by a brief spell as a Research Associate at Leicester University. He joined the Medical and Molecular Genetics group at the University 麻豆精选 where he went on to study for a PhD in Molecular Genetics. In 2011 he was appointed as a lecturer in Cardiovascular Sciences at the University 麻豆精选 and promoted to Senior Lecturer in 2016, to Reader in 2020 and subsequently to Professor in 2021.

Teaching

Postgraduate supervision

Neil is interested in supervising doctoral research students in the following areas:

  • Gene identification of inherited bleeding disorders
  • Next generation sequencing technologies in human disease gene identification
  • Platelet and Megakaryocyte Biology of novel disease genes mutated in inherited thrombocytopenia
  • Phenotyping and functional testing of Bleeding Disorders of Unknown Cause (BDUC)

Current PhD students:  Zoe Markham-Lee, Natasha Pavey, Ravinder Bhardwaj

Current Postdoctoral research fellows: Dr Xenia Sawkulycz

Alumni PhD students: Ben Johnson, Jane Futterer, Atif Alsaedi, Abdullah Khan, Annabel Maclachlan, Emily Colley, Ibrahim Almazni, Rachel Stapley,

Alumni Postdoctoral research fellows: Dr Sarah Fletcher, Dr Abdullah Khan, Rachel Stapley

Research

A major aim of his research at the University 麻豆精选 has been to identify novel genes for inherited diseases to allow improved genetic diagnosis and gain important insights into the pathogenesis of the disorder and elucidate the function of the disease gene. His current research is focusing on the molecular genetics of patients with platelet-based bleeding disorders and low platelet counts (thrombocytopenia). He utilises the latest next generation sequencing technologies to identify novel gene defects providing clues to genes and proteins involved in normal platelet physiology which will ultimately lead to devising new treatment strategies to minimise the risk of bleeding in such patients.

His past research has primarily involved identification of the novel genes for inherited diseases of the haematopoietic system. He has been extremely successful in his pursuit and key findings include: 

  • SLFN14 mutations causing an inherited bleeding disorder with thrombocytopenia and platelet secretion defects
  • TRAC mutations causing a novel immunodeficiency disorder  
  • SLC29A3 mutations causing familial Faisalabad histiocytosis/Rosai-Dorfman disease
  • BLOC1S3 mutations causing a novel form of Hermansky Pudlak disorder (HPS8)
  • CHRNG, RAPSN and DOK7 mutations causing multiple pterygia syndrome/foetal akinesia deformation sequence
  • PLA2G6 mutations causing a spectrum of childhood onset neurodegenerative disorders associated with brain iron accumulation
My Research with Dr Neil Morgan

Other activities

  • Chief investigator of the Genotyping and Phenotyping of Platelets (GAPP) study  for the management and recruitment of patients with inherited bleeding disorders.
  • Speciality Chief Editor :  
  • Principal Editor for the
  • Treasurer of the  
  • domain for Immunology and Haematology (Member)
  • Institute of Cardiovascular Sciences representative for Genomics, including the 100K Genome Collection Centre (Lead)
  • Contribute to the newly established .  Advise and provide website information for patients and their families with platelet function disorders
  • Advisor to . Funny Blood raises awareness of Platelet Function Disorders (PFDs), signposts information to support families living with the little-known condition and fundraises for the ongoing care of sufferers at the Haemophilia Unit in
  • , speaking at BHF/West Midlands Heart supporter group events and BHF Community Fundraising Conferences.  

Publications

Recent publications

Article

D铆az-Ajenjo, L, Mar铆n-Qu铆lez, A, Lama-Villanueva, A, Garc铆a-Ja茅n, P, Rey-Bua, B, Hern谩ndez-Rivas, JM, Morgan, NV, Gonz谩lez-Porras, JR, Benito, R, Rivera, J & Bastida Bermejo, JM 2025, '', Journal of Thrombosis and Haemostasis.

Huang, J, Marini, F, Solari, FA, Swieringa, F, de Laat, B, De Simone, I, Grassi, L, Gui, X, Li, K, Middleton, EA, Morgan, NV, Provenzale, I, Santos, C, Schols, S, Westbury, S, Sickmann, A, Rondina, MT, Ruf, W, Frontini, M & Heemskerk, JWM 2025, '', Blood vessels, thrombosis & hemostasis, vol. 2, no. 3, 100068.

Di Buduo, CA, Abbonante, V, Malara, A, Balduini, A, Waller, AK, Watson, SP, Martin, EM, Bridge, L, Gibbins, J, Hers, I, Masson, C, Eckly, A, Poulter, NS, Mart铆nez-Garc铆a, B, Aguila, S, Gresele, P, Momi, S, Amstrong, P, Rondina, M, Troiti帽o, S, Garc铆a, 脕, Bastida, JM, Quilez, AM, Fuentes, AS, Rivera, J, Torres-Ruiz, R, Ojeda-Walczuk, P, Morgan, NV, Morena, BDL, Ramaekers, K, Tran, M, De Wispelaere, K, Freson, K, Bergmeier, W, Greinacher, A, He, F, Oh, S, Di Paola, J, Semple, JW, Lozano, ML, Llamas, P & Ward, C 2025, '', Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 2, 102715.

Stapley, RJ, Sawkulycz, X, Da Mota Araujo, GHM, Englert, M, Garcia-Quintanilla, L, Smith, SRM, Ahmed, A, Haining, EJ, Kaur, N, Bacon, A, Pisarev, AV, Poulter, NS, Kavanagh, DPJ, Thomas, SG, Montague, SJ, Rayes, J, Nagy, Z & Morgan, NV 2025, '', Journal of Clinical Investigation.

Luo, M, Jia, X, Wang, Z-W, Yang, J-Y, Wang, W, Chen, J, Ou, J-Y, Feng, J-X, Yu, B, Wang, S, Huang, L, Morgan, N, Deng, K, Chen, T, Zhang, Q & Gao, S 2025, '', Nucleic Acids Research, vol. 53, no. 10, gkaf484.

Noureddine, M, Mikolajek, H, Morgan, N, Denning, C, Loughna, S, Gehmlich, K & Mohammed, F 2025, '', Journal of General Physiology, vol. 157, no. 2, e202413684.

Smith, SRM, Morgan, N & Brill, A 2025, '', Blood Advances.

Montague, SJ, Price, J, Pennycott, K, Pavey, NJ, Martin, EM, Thirlwell, I, Kemble, S, Monteiro, C, Redmond-Motteram, L, Lawson, N, Reynolds, K, Fratter, C, Bignell, P, Groenheide, A, Huskens, D, Laat, BD, Pike, JA, Poulter, NS, Thomas, SG, Lowe, GC, Lancashire, J, Harrison, P & Morgan, NV 2024, '', Journal of Thrombosis and Haemostasis, vol. 22, no. 8, pp. 2281-2293.

Reyat, J, Sommerfeld, L, O'Reilly, M, Roth Cardoso, V, Thiemann, E, Khan, A, O'Shea, C, Harder, S, M眉ller, C, Barlow, J, Stapley, R, Chua, WWL, Kabir, N, Grech, O, Hummel, O, H眉bner, N, Kaab, S, Mont, L, Hatem, SN, Winters, J, Zeemering, S, Morgan, N, Rayes, J, Gehmlich, K, Stoll, M, Brand, T, Schweizer , M, Piasecki, A, Schotten, U, Gkoutos, G, Lorenz, K, Cuello, F, Kirchhof, P & Fabritz, L 2024, '', Cardiovascular Research.

Barrachina, MN, Pernes, G, Becker, IC, Allaeys, I, Hirsch, TI, Groeneveld, DJ, Khan, AO, Freire, D, Guo, K, Carminita, E, Morgan, PK, Collins, TJC, Mellett, NA, Wei, Z, Almazni, I, Italiano, JE, Luyendyk, J, Meikle, PJ, Puder, M, Morgan, NV, Boilard, E, Murphy, AJ & Machlus, KR 2023, '', Nature Cardiovascular Research, vol. 2, no. 8, pp. 746-763.

Ross, JE, Mohan, S, Zhang, J, Sullivan, MJ, Bury, L, Lee, K, Futchi, I, Frantz, A, McDougal, D, Perez Botero, J, Cattaneo, M, Cooper, N, Downes, K, Gresele, P, Keenan, C, Lee, A, Megy, K, Morange, P, Morgan, N, Schulze, H, Zimowski, K, Freson, K & P.Lambert, M 2023, '', Thrombosis and Haemostasis.

Homan, CC, Drazer, MW, Yu, K, Lawrence, DM, Feng, J, Arriola-Martinez, L, Pozsgai, MJ, McNeely, KE, Ha, T, Venugopal, P, Arts, P, King-Smith, SL, Cheah, J, Armstrong, M, Wang, P, B枚d枚r, C, Cantor, AB, Cazzola, M, Degelman, E, DiNardo, CD, Duployez, N, Favier, R, Fr枚hling, S, Rio-Machin, A, Klco, JM, Kr盲mer, A, Kurokawa, M, Lee, J, Malcovati, L, Morgan, NV, Natsoulis, G, Owen, C, Patel, KP, Preudhomme, C, Raslova, H, Rienhoff, H, Ripperger, T, Schulte, R, Tawana, K, Velloso, E, Yan, B, Kim, E, Sood, R, Hsu, AP, Holland, SM, Phillips, K, Poplawski, NK, Babic, M, Wei, AH, Forsyth, C, Mar Fan, H, Lewis, ID, Cooney, J, Susman, R, Fox, LC, Blombery, P, Singhal, D, Hiwase, D, Phipson, B, Schreiber, AW, Hahn, CN, Scott, HS, Liu, P, Godley, LA & Brown, AL 2023, '', Blood Advances, vol. 7, no. 20, pp. 6092-6107.

Editorial

Morgan, NV 2023, '', Frontiers in cardiovascular medicine, vol. 10, 1282147.

Letter

Hassan, E, Fratter, C, Lester, W, Percy, C, Saad, W, Alkhedir, A, Motwani, J, Bagnell, P, Nicolson, PLR, Morgan, NV, Potluri, S & Lowe, G 2025, '', Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 3, 102869.

Review article

Aikawa, M, Sonawane, AR, Chelvanambi, S, Asano, T, Halu, A, Matamalas, JT, Singh, SA, Uchida, S, Aikawa, E, Arenas, A, Balligand, C, MacRae, CA, Oury, C, Morgan, N, Tevaearai Stahel, H & Loscalzo, J 2025, '', Frontiers in cardiovascular medicine, vol. 3, 1474469.