Dr Mark Thomas BMedSci, BMBS, MRCP, PhD

Dr Mark Thomas

Department of Cardiovascular Sciences
Associate Professor of Cardiology and Honorary Consultant Cardiologist

Contact details

Telephone
+44 (0)121 414 8679
Email
m.r.thomas@bham.ac.uk
Address
Cardiovascular Sciences
College of Medicine and Health
University 麻豆精选
Edgbaston
Birmingham
B15 2TT
UK

Dr Mark Thomas is an Associate Professor of Cardiology and Honorary Consultant Cardiologist working at the University 麻豆精选 and University Hospitals Birmingham NHS Foundation Trust. The main focus of Mark’s work is translational research that has the potential to benefit patients with coronary artery disease. He is particularly interested in improving antithrombotic treatments and using data science/AI to optimise the treatment of patients who have had heart attacks.

Department of Cardiovascular Sciences Research Theme: Thrombosis and Haemostasis

Qualifications

  • PhD Antiplatelet pharmacology – University of Sheffield
  • MRCP – Royal College of Physicians, London
  • BMBS – University of Nottingham
  • BSc Biomedical Sciences (First Class Hons) – University of Nottingham

Biography

Dr Mark Thomas completed his medical training at the University of Nottingham and was awarded the AZ Research and Development prize for his BMedSci thesis. He was subsequently awarded a Young Investigator Award by the International Society on Thrombosis and Haemostasis and the Bedi Cardiovascular Medicine Prize by the University of Nottingham for his work related to antiplatelet therapy.

During Mark's MRC Clinical Research Training Fellowship and NIHR Clinical Lectureship he developed expertise in molecular and cellular pharmacology and uses a wide range of laboratory-based techniques, including detailed assessment of platelet function, flow and mass cytometry and advanced imaging techniques. 

Mark strongly believes that data science and machine learning have the potential to transform clinical medicine. He has therefore undertaken training in computer science and has the ability to write software using advanced Python and R programming skills. In addition, he has Specialization certificates in AI in Healthcare (Stanford University, Coursera) and Data Science (Johns Hopkins University, Coursera).

Mark is currently an Associate Professor of Cardiology at the University 麻豆精选, where he is developing clinical trials to investigate novel GPVI inhibitors as new treatments for acute coronary syndromes. He is an honorary consultant cardiologist at Queen Elizabeth Hospital Birmingham and his clinical practice focuses on complex pharmacology, preventative cardiology and cardiac CT, in addition to acute/general cardiology.

Teaching

  • Lectures for undergraduate students
  • Lectures for postgraduate students
  • Bedside-teaching for medical students

Postgraduate supervision

  • Supervision of BSc Biomedical Sciences  students
  • Supervision of MD/PhD students
  • Supervision of Masters students

Research

Cardiovascular Research with Dr Mark Thomas

Mark’s most recent research focuses on novel antiplatelet treatments for patients with acute coronary syndromes. In addition, he is initiating  studies that investigate novel predictors of bleeding and adverse cardiovascular events in patients with acute coronary syndromes.

Mark has previously investigated whether antiplatelet medications affect systemic inflammation, as this may contribute to their clinical benefit in-vivo. He has also performed several studies investigating the clinical relevance of the pharmacokinetic and pharmacodynamics of antiplatelet therapy in patients with cardiovascular disease.

Other activities

  • Chair of European Society of Cardiology Young Thrombosis Researchers Group 2014-2016
  • Co-investigator/sub-investigator for multinational cardiovascular clinical trials including PEGASUS-TIMI 54, ATLANTIC, ENGAGE-AF TIMI 48, THEMIS, CANTOS and ODYSSEY-OUTCOMES.
  • Principal Editor of Platelets journal 2016-
  • Member of the Working Group on Thrombosis of the European Society of Cardiology from 2013-

Publications

Recent publications

Article

Slater, A, Khattak, S & Thomas, MR 2024, '', European heart journal. Cardiovascular pharmacotherapy.

Smith, C, Campos, J, Brown, H, Ivanova, V-S, Harbi, M, Garcia Quintanilla, L, Jossi, S, Perez-Toledo, M, Rookes, K, Brill, A, Theodore, L, Owens, T, LaStant, J, Foulke, MC, Mukai, S, Francesco, M, Storek, M, Hicks, A, Langrish, C, Nunn, PA, Cunningham, A, Chauhan, A, Thomas, MR, Watson, S & Nicolson, P 2024, '', Blood Advances.

Alenazy, F, Harbi, M, Kavanagh, D, Price, J, Brady, P, Hargreaves, O, Harrison, P, Slater, A, Tiwari, A, Nicolson, P, Connolly, D, Kirchhof, P, Kalia, N, Jandrot-Perrus, M, Mangin, PH, Watson, S & Thomas, MR 2023, '', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 11, pp. 3236-3251.

Damaskinaki, F-N, Jooss, NJ, Martin, EM, Clark, JC, Thomas, MR, Poulter, NS, Emsley, J, Kellam, B, Watson, SP & Slater, A 2023, '', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 2, pp. 317-328.

Scott, P, Heigl, M, McCay, C, Shepperdson, P, Lima鈥怶alton, E, Andrikopoulou, E, Brunnhuber, K, Cornelius, G, Faulding, S, McAlister, B, Rowark, S, South, M, Thomas, MR, Whatling, J, Williams, J, Wyatt, JC & Greaves, F 2023, '', Learning Health Systems.

Jooss, NJ, Smith, CW, Slater, A, Montague, SJ, Di, Y, O'shea, C, Thomas, MR, Henskens, YMC, Heemskerk, JWM, Watson, SP & Poulter, NS 2022, '', Journal of Thrombosis and Haemostasis, vol. 20, no. 11, pp. 2617-2631.

Harbi, M, Smith, C, Alenazy, F, Nicolson, P, Tiwari, A, Watson, S & Thomas, MR 2022, '', International Journal of Molecular Sciences, vol. 23, no. 13, 6982.

Bourne, J, Smith, C, Jooss, N, Di, Y, Brown, H, Montague, S, Thomas, M, Poulter, N, Rayes, J & Watson, SP 2022, '', Thrombosis and Haemostasis, vol. 122, no. 12, pp. 1988-2000.

Brady, PF, Chua, W, Nehaj, F, Connolly, DL, Khashaba, A, Purmah, YJV, Ul-Qamar, MJ, Thomas, MR, Varma, C, Schnabel, RB, Zeller, T, Fabritz, L & Kirchhof, PF 2022, '', Journal of the American Heart Association, vol. 11, no. 4, e022833.

Colicchia, M, Schrottmaier, WC, Perrella, G, Reyat, JS, Begum, J, Slater, A, Price, J, Clark, JC, Zhi, Z, Simpson, M, Bourne, J, Poulter, NS, Khan, AO, Nicolson, PLR, Pugh, MR, Harrison, P, Iqbal, AJ, Rainger, GE, Watson, SP, Thomas, MR, Mutch, NJ, Assinger, A & Rayes, J 2022, '', Blood.

Smith, C, Harbi, M, Garcia Quintanilla, L, Rookes, K, Brown, H, Poulter, N, Watson, S, Nicolson, P & Thomas, MR 2022, '', Journal of Thrombosis and Haemostasis.

Cooper, NI, Altomare, I, Thomas, MR, Nicolson, P, Watson, S, Markovtsov, V, Todd, LK, Masuda, E & Bussel, JB 2021, '', Therapeutic Advances in Hematology, vol. 12, 20406207211010875.

Perrella, G, Huang, J, Provenzale, I, Swieringa, F, Heubel-Moenen, F, Farndale, RW, Roest, M, Van Der Meijden, P, Thomas, M, Ari毛ns, RAS, Jandrot-Perrus, M, Watson, S & Heemskerk, JWM 2021, '', Arteriosclerosis Thrombosis and Vascular Biology, vol. 41, no. 2, pp. e97鈥揺111.

Review article

Khattak, S, Townend, JN & Thomas, MR 2024, '', Frontiers in Molecular Biosciences, vol. 11, 1287553.

Thomas, MR & Nicolson, P 2021, '', Platelets, vol. 32, no. 1, pp. 5-6.