Professor Andy Wilson FRSC, FHEA

Professor Andy Wilson

School of Chemistry
Professor of Chemical Biology

Contact details

Email
a.j.wilson.1@bham.ac.uk
Twitter
Address
School of Chemistry
University 麻豆精选
Edgbaston
Birmingham
B15 2TT
UK

Andy Wilson is a Professor in the School of Chemistry

The are interested in the application of synthetic molecules to problems in Chemical Biology and Materials Science. We pursue both curiosity driven fundamental research and mission inspired research addressing societal challenges.

The group is currently supported by The University 麻豆精选, EPSRC and BBSRC.

Our group is participating in several large-scale, multi-investigator programmes including , a major BBSRC investment, and led on the EPSRC  Programme.

Qualifications

PhD in Synthetic Chemistry with Professor David A. Leigh FRS, “The Controlled Assembly of Interlocked Architectures”. University of Warwick 1998-2000, The University of Manchester Institute of Science and Technology (UMIST) 1997-1998. 2000

 BSc (Hons) Chemistry 1st Class at UMIST 1997

Publications

M. A. Jinks, M. Howard, F. Rizzi, S. M. Goldup, A. D. Burnett, A. J. Wilson*: Direct Detection of Hydrogen Bonds in Supramolecular Systems Using 1H-15N Heteronuclear Multiple Quantum Coherence Spectroscopy, J. Am. Chem. Soc., 2022, 50, 23127-23133. .

T. Ueda, T. Tamura, M. Kawano, K. Shiono, F. Hobor, A. J. Wilson, I. Hamachi*: Enhanced suppression of a protein-protein interaction in cells using small-molecule covalent inhibitors based on N-acyl-N-alkyl sulfonamide warhead, J. Am. Chem. Soc. , 2021, 143, 4766-4774. .

S. Celis, F. Hobor, T. James, G. J. Bartlett, A. A. Ibarra, D. K. Shoemark, Z. Hegedus, K. Hetherington, D. N. Woolfson, R. B. Sessions, T. A. Edwards, D. M. Andrews,* A. Nelson,* A. J. Wilson*: Query-Guided Protein-Protein Interaction Inhibitor Discovery, Chem. Sci., 2021, 12, 4753-4762. .

Z. Hegedüs, F. Hobor, D. K Shoemark, L.-Y. Lian, C. Trinh, R. B. Sessions, T. A. Edwards, A. J. Wilson*: Identification of β-Strand Mediated Protein-Protein Interaction Inhibitors Using Ligand-Directed Fragment Ligation, Chem. Sci., 2021, 12, 2286-2293. .

E. E. Cawood, N. Guthertz, J. Ebo, T. K. Karamanos, S. E. Radford,* A. J. Wilson*: Modulation of amyloidogenic protein self-assembly using tethered small molecules, J. Am. Chem. Soc., 2020, 142, 20845-20854. .

S. J. Bunce, Y. Wang, K. L. Stewart, A. E. Ashcroft, S. E. Radford,* C. K. Hall,* A. J. Wilson*: Molecular Insights into the surface catalyzed secondary nucleation of Amyloid-β40 (Aβ40) by the peptide fragment Aβ16-22, Sci. Adv., 2019, 5, eaav8216. .

J. E. Horne, M. Walko, A. N. Calabrese, M. A. Levenstein, D. J. Brockwell, N. Kapur, A. J. Wilson*, S. E. Radford*: Rapid Mapping of Protein Interactions Using Tag-Transfer Photocrosslinkers, Angew. Chemie. Int. Ed., 2018, 57, 16688–16692. .

J. M. Fletcher, K. A. Horner, G. J Bartlett, G. R. Rhys, A. J. Wilson,* D. N. Woolfson*: De novo coiled-coil peptides as scaffolds for disrupting protein-protein interactions, Chem. Sci., 2018, 9, 7656-7665. .

J. A. Miles, D. J. Yeo, Philip Rowell, S. Rodriguez-Marin, C. M. Pask, S. L. Warriner, T. A. Edwards*, A. J. Wilson*: Hydrocarbon Constrained Peptides – Understanding Preorganization and Binding Affinity, Chem. Sci., 2016, 7, 3694-3702. .

A. Barnard, K. Long, H. L. Martin, J. A. Miles, T. A. Edwards, D. C. Tomlinson, A. Macdonald,* A. J. Wilson*: Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions, Angew. Chem. Int. Ed. , 2015, 54, 2960-2965. .