Dr Andrew P Holmes BMedsc PhD

Dr Andrew P Holmes

Department of Biomedical Sciences
Lecturer in Cardiac and Respiratory Physiology
Next Generation Biotechnology Theme Lead

Contact details

Telephone
+44 (0)121 415 8161
Email
a.p.holmes@bham.ac.uk
Address
University 麻豆精选
Edgbaston
Birmingham
B15 2TT
UK

Andrew Holmes is a Lecturer in Cardiac and Respiratory Physiology in the Department of Biomedical Sciences.

His research interests are in the field of cardiovascular and respiratory physiology and pathology, with an emphasis on identifying novel mechanisms underlying hypertension and cardiac arrhythmia.

Dr Holmes has a key research focus on evaluating how cardiorespiratory reflex dysfunction caused by hyperactive carotid body chemoreceptors promotes hypertension and cardiac autonomic dysfunction. He aims to develop new or repurposed therapies that directly target the carotid body to reduce hypertension and arrhythmia in associated diseases such as obstructive sleep apnoea and COPD. This work is currently supported by the Wellcome Trust.

In addition, he has a specific interest in understanding how acute and chronic hypoxia disrupt the electrical integrity of atrial tissue leading to heart rhythm disturbances. This work is currently supported by grants from BHF.  

Dr Holmes is an enthusiastic teacher and contributes to the delivery of both undergraduate and postgraduate courses. He is joint module lead on the Biomedical Science BSc Year 3 module- Hypoxia in Health and Disease.

Qualifications

  • PhD in Medical Science, University 麻豆精选, 2013
  • BMedSc (Hons), Class I, University 麻豆精选, 2009

Teaching

Dr Holmes is an enthusiastic teacher and understands the importance of delivering high quality research led and research informed content to undergraduate students.

Undergraduate teaching:

  • Biomedical Science BSc
    • Joint Module Lead on Hypoxia in Health and Disease (2018 - present)
    •  Cardiorespiratory 1 and 2 (2013-present)
    • Digestion and Renal Sciences (2018-present)
    • Cellular Biochemistry and Biology (2018-present)
  • Medicine and Surgery MBChB 
    • Introduction to Respiratory Medicine (2018- present)
    • Cardiovascular Sciences (2018- present)
    • Digestion (2018- present)
  • Dental Surgery BDS
    • Cardiovascular Pharmacology (2018- present)

Small group laboratory practical sessions:

  • Biomedical Science BSc
    • Studying the alterations in electrical properties of atrial cardiomyocytes induced by hypoxia and re-oxygenation (2014- present).

Dr Holmes also currently supervises undergraduates working on their final year research projects.

Other activities

  • Member of the Physiological Society
  • Member of the European Society of Cardiology
  • Dr Holmes is a tutor on the Access to Birmingham (A2B) Scheme that aims to encourage under-privileged students to consider and prepare for admission into a medical/scientific degree course.

Publications

Recent publications

Article

Roy, A, Cumberland, M, O'Shea, C, Holmes, A, Kalla, M, Gehmlich, K, Geberhiwot, T & Steeds, R 2024, '', Current cardiology reports.

Cumberland, M, Euchner, J, Azad, A, Vo, NTN, Kirchhof, P, Holmes, A, Denning, C & Gehmlich, K 2024, '', F1000Research, vol. 12, 1224.

Sommerfeld, LC, Holmes, AP, Yu, TY, O'Shea, C, Kavanagh, DM, Pike, JM, Wright, T, Syeda, F, Aljehani, A, Kew, T, Cardoso, VR, Kabir, SN, Hepburn, C, Menon, PR, Broadway鈥怱tringer, S, O'Reilly, M, Witten, A, Fortmueller, L, Lutz, S, Kulle, A, Gkoutos, GV, Pavlovic, D, Arlt, W, Lavery, GG, Steeds, R, Gehmlich, K, Stoll, M, Kirchhof, P & Fabritz, L 2024, '', The Journal of Physiology.

Holmes, AP & Kumar, P 2023, '', Experimental Physiology, vol. 108, no. 2, pp. 167-168.

Cumberland, M, Riebel, LL, Roy, A, O'Shea, C, Holmes, A, Denning, C, Kirchhof, P, Rodriguez, B & Gehmlich, K 2022, '', Frontiers in Physiology, vol. 13, 806366.

Al-Maswary, AA, O'Reilly, M, Holmes, AP, Walmsley, AD, Cooper, PR & Scheven, BA 2022, '', PLoS ONE, vol. 17, no. 11, e0277134.

O'Reilly, M, Sommerfeld, LC, O'Shea, C, Broadway-Stringer, S, Andaleeb, S, Reyat, JS, Kabir, SN, Stastny, D, Malinova, A, Delbue, D, Fortmueller, L, Gehmlich, K, Pavlovic, D, Skryabin, BV, Holmes, AP, Kirchhof, P & Fabritz, L 2022, '', EP Europace.

O鈥橲hea, C, Winter, J, Kabir, SN, O鈥橰eilly, M, Wells, SP, Baines, O, Sommerfeld, LC, Correia, J, Lei, M, Kirchhof, P, Holmes, AP, Fabritz, L, Rajpoot, K & Pavlovic, D 2022, '', Scientific Data, vol. 9, no. 1, 135.

O'Brien, S-M, Holmes, A, Johnson, D, Kabir, SN, O'Shea, C, O'Reilly, M, Avezzu, A, Reyat, J, Hall, AW, Apicella, C, Ellinor, PT, Niederer, S, Tucker, NR, Fabritz, L, Kirchhof, P & Pavlovic, D 2022, '', Journal of Molecular and Cellular Cardiology, vol. 166, pp. 23-35.

Abstract

Briggs, D, Hunt, J, Raut, S, Saleeb-Mousa, J, Coney, A, Kalla, M, Holmes, A & Brain, K 2024, '', Congress of The International Society for Autonomic Neuroscience, Birmingham, United Kingdom, 25/07/24 - 27/07/24 pp. 177-177. <>

Conference contribution

Aldossary, HS, Nieves, DJ, Kavanagh, DM, Owen, D, Ray, CJ, Kumar, P, Coney, AM & Holmes, AP 2023, . in SV Conde, R Iturriaga, R del Rio, E Gauda & EC Monteiro (eds), Arterial Chemoreceptors: Mal(adaptive) Responses: O2 Dependent and Independent Mechanisms. 1 edn, Advances in Experimental Medicine and Biology, vol. 1427, Springer, pp. 175-184, ISAC XXI 2022, Lisbon, Portugal, 27/06/22.

Review article

Sha, R, Baines, O, Hayes, A, Tompkins, K, Kalla, M, Holmes, AP, O'Shea, C & Pavlovic, D 2024, '', Journal of the American Heart Association, vol. 13, no. 1, e032277.

Baines, O, Sha, R, Kalla, M, Holmes, AP, Efimov, IR, Pavlovic, D & O鈥橲hea, C 2024, '', Europace, vol. 26, no. 2, euae017, pp. 1-14.

Saleeb-Mousa, J, Nathanael, D, Coney, AM, Kalla, M, Brain, KL & Holmes, AP 2023, '', Cells, vol. 12, no. 12, 1661.

Holmes, AP, Swiderska, A, Nathanael, D, Aldossary, HS, Ray, CJ, Coney, AM & Kumar, P 2022, '', Frontiers in Physiology, vol. 13, 908617.