Dr Adrian Shields MBBS, MRCP, PhD

Adrian Shields

Department of Immunology and Immunotherapy
Clinical Lecturer

Contact details

Telephone
+44 (0)121 414 4069
Email
a.m.shields@bham.ac.uk
Twitter
Address
Department of Immunology and Immunotherapy
College of Medicine and Health
University 麻豆精选
Edgbaston
Birmingham
B15 2TT
UK

Adrian Shields is a clinical immunologist interested in understanding the mechanisms that protect us from infections and how those systems fail in individuals with primary and secondary immunodeficiencies.

His recent work has described risk factors for severe COVID-19 in individuals with immunodeficiencies and understanding the antibody response to SARS-CoV-2 in large cohorts of health care workers

Qualifications

Clinical Lecturer in Immunology

  • MCRP – 2015
  • MBBS – 2012
  • PhD in Immunology – 2010
  • BSc (Hons) in Immunobiology and Infectious Disease - 2006

Biography

Adrian studied medicine at King’s College London, undertaking an intercalated PhD in 2006 investigating non-invasive gene delivery as an approach to treat inflammatory arthritis.

He went on to undertake further research projects with Dr Mike Lunn in at the Institute of Neurology, University College London looking for novel autoantigens in paraneoplastic neurological syndromes, with Dr Myles Lewis at the Department of Medical Genetics at King’s College London examining the role of ubiquitin conjugating enzymes in systemic lupus erythematosus and finally with Prof Graham Ogg at the Weatherall Institute of Molecular Medicine in Oxford, looking at proteomic signatures in allergic dermatitis.

His medical training included placements across various South London teaching hospitals before specialty training in Clinical Immunology in Oxford and Birmingham.

Adrian currently chairs the West Midlands regional immunogenomics multi-disciplinary meeting where the results of next-generation sequencing panels for patients with immunodeficiencies are reported and interpreted.

His research interests include the cellular and molecular mechansism underlying primary and secondary immunodeficiency and assay development to understand and interpret genetic variants of unknown significance.

Teaching

  • MBChB
    • Year 3 Immunology module
    • Year 2  Immunology module
  • MPharm
    • Year 2 Immunology module

Postgraduate supervision

Enquires should be directed to a.m.shields@bham.ac.uk

Research

Research interests

  • Primary immunodeficiency
  • Secondary immunodeficiency
  • Genomic medicine in immmodeficiency
  • Immunoassay development

Current projects

  • Understanding the systemic and mucosal antibody responses to SARS-CoV-2 in mild and moderate COVID-19
  • Risk factors for severe COVID-19 in patients with primary and secondary immunodeficiency
  • Development of clinical and laboratory biomarkers to define the severity of secondary immunodeficiency

Other activities

  • Chair of the West Midlands Immunogenomics multi-disciplinary meeting
  • Clinical interest in primary and secondary immunodeficiencies, particularly complex secondary immunodeficiency following stem cell transplantation.

Publications

Recent publications

Article

Griffiths, K, Mellado, MR, Chung, R, Lally, J, McQueen, G, Sendt, K-V, Gillespie, A, Ibrahim, M, Richter, A, Shields, A, Ponsford, M, Jolles, S, Hodsoll, J, Pollak, TA, Upthegrove, R, Egerton, A & Maccabe, JH 2024, '', Brain, Behavior, and Immunity, vol. 115, pp. 223-228.

Faustini, SE, Hodson, J, Birtwistle, J, Whitelegg, A, Masuka, S, Singo, M, Chigiga, J, Shields, A, Plant, T, Drayson, MT, Manavi, K, MacLennan, CA & Richter, AG 2024, '', Journal of Infection, vol. 89, no. 5, 106282.

Dimbleby, B, Greenway, W, Burns, SO, Richter, AG & Shields, AM 2025, '', Journal of Clinical Immunology, vol. 45, no. 1, 18.

Smith, P, Chicca, I, Heaney, J, Muchov谩, M, Khanim, F, Shields, A, Drayson, M, Chapple, I & Hirschfeld, J 2024, '', Chemico-Biological Interactions, vol. 404, 111283.

PANORAMIC Virology Group, Standing, JF, Buggiotti, L, Guerra-Assuncao, JA, Woodall, M, Ellis, S, Agyeman, AA, Miller, C, Okechukwu, M, Kirkpatrick, E, Jacobs, AI, Williams, CA, Roy, S, Martin-Bernal, LM, Williams, R, Smith, CM, Sanderson, T, Ashford, FB, Emmanuel, B, Afzal, ZM, Shields, A, Richter, AG, Dorward, J, Gbinigie, O, Van Hecke, O, Lown, M, Francis, N, Jani, B, Richards, DB, Rahman, NM, Yu, L-M, Thomas, NPB, Hart, ND, Evans, P, Andersson, M, Hayward, G, Hood, K, Nguyen-Van-Tam, JS, Little, P, Hobbs, FDR, Khoo, S, Butler, C, Lowe, DM & Breuer, J 2024, '', Nature Communications, vol. 15, no. 1, 1652.

Chadda, KR, Roberts, SA, Lugg, ST, Faniyi, AA, Faustini, SE, Webster, C, Duffy, JE, Hewison, M, Shields, A, Richter, AG, Parekh, D, Scott, A & Thickett, DR 2024, '', Frontiers in Medicine, vol. 11, 1494129.

Shields, AM, Faustini, SE, Young, S, Terjesen, S, McCarthy, NI, Anderson, RL, Drayson, MT & Richter, AG 2023, '', EJHaem, vol. 4, no. 2, pp. 339-349.

Jones, R, Morales-Munoz, I, Shields, A, Blackman, G, Legge, SE, Pritchard, M, Kornblum, D, MacCabe, JH & Upthegrove, R 2023, '', Brain, Behavior, and Immunity, vol. 113, pp. 267-274.

PITCH Consortium, Moore, SC, Kronsteiner, B, Longet, S, Adele, S, Deeks, AS, Liu, C, Dejnirattisai, W, Reyes, LS, Meardon, N, Faustini, S, Al-Taei, S, Tipton, T, Hering, LM, Angyal, A, Brown, R, Nicols, AR, Dobson, SL, Supasa, P, Tuekprakhon, A, Cross, A, Tyerman, JK, Hornsby, H, Grouneva, I, Plowright, M, Zhang, P, Newman, TAH, Nell, JM, Abraham, P, Ali, M, Malone, T, Neale, I, Phillips, E, Wilson, JD, Murray, SM, Zewdie, M, Shields, A, Horner, EC, Booth, LH, Stafford, L, Bibi, S, Wootton, DG, Mentzer, AJ, Conlon, CP, Jeffery, K, Matthews, PC, Pollard, AJ, Brown, A, Rowland-Jones, SL, Mongkolsapaya, J, Payne, RP, Dold, C, Lambe, T, Thaventhiran, JED, Screaton, G, Barnes, E, Hopkins, S, Hall, V, Duncan, CJA, Richter, A, Carroll, M, De Silva, TI, Klenerman, P, Dunachie, S, Turtle, L & Efstathiou, E 2023, '', Med, vol. 4, no. 3, pp. 191-215.e9.

Faustini, SE, Cook, A, Hill, H, Al-Taei, S, Heaney, J, Efstathiou, E, Tanner, C, Townsend, N, Ahmed, Z, Dinally, M, Hoque, M, Goodall, M, Stamataki, Z, Plant, T, Chapple, I, Cunningham, AF, Drayson, MT, Shields, AM & Richter, AG 2023, '', Journal of Infection, vol. 87, no. 4, pp. 328-335.

Ward, KE, Steadman, L, Karim, AR, Reynolds, GM, Pugh, M, Chua, W, Faustini, SE, Veenith, T, Thwaites, RS, Openshaw, PJM, Drayson, MT, Shields, AM, Cunningham, AF, Wraith, DC & Richter, AG 2023, '', Clinical and Experimental Immunology, vol. 213, no. 2, pp. 243-251.

Abstract

Roberts, SA, Lugg, ST, Faniyi, AA, Faustini, SE, Faniyi, C, Duffy, J, Hewison, M, Shields, A, Richter, AG, Parekh, D, Scott, A & Thickett, DR 2023, '', Thorax, vol. 77, no. Suppl 1, pp. A170-A171.

Letter

Ho, A, Galgut, O, Faustini, S, Peters, N, Shields, A, Klenerman, P, Hopkins, S, Hall, V, Dunachie, S & Richter, A 2024, '', The Lancet, vol. 404, no. 10447, pp. 23-24.

Fink, DL, Idilli, O, Shields, A, Richter, A & Burns, SO 2024, '', Journal of Clinical Immunology, vol. 44, 161.

Elhaj, MO, Richter, AG, Goddard, S & Shields, AM 2023, '', British Journal of Haematology, vol. 202, no. 4, pp. 900-903.