Dr Palak Trivedi BSc (hons), MBBS, MRCP Gastro (UK), PhD

Palak Trivedi

Department of Immunology and Immunotherapy
Associate Professor and Honorary Consultant Hepatologist
Clinical Research Director for Industry Engagement

Contact details

Telephone
+44 (0)121 371 8173
Email
p.j.trivedi@bham.ac.uk
Twitter
Address
NIHR Birmingham BRC
Centre for Liver and Gastrointestinal Research
Department of Immunology and Immunotherapy
ITM Building, Mindelsohn Way
University 麻豆精选
Edgbaston
Birmingham
B15 2TT
UK

Dr. Trivedi is a Clinician Scientist in the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (BRC), based at the University 麻豆精选. Dr. Trivedi is a Consultant Hepatologist who has devoted his clinical and research career to studying immune-mediated and chronic cholestatic liver disease, specifically primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC).

Palak is chief investigator for the UK-PSC consortium, and was elected chair of the British Association for Study of the Liver Special Interest Group (BASL SIG) for immune-mediated liver disease in 2018.

Qualifications

  • PhD in liver Immunology, University 麻豆精选, 2015
  • Member of the Royal College of Physicians, London, 2008
  • MBBS, St. George’s Hospital Medical School, London, 2005
  • BSc (hons) in Medical Genetics, St. George’s Hospital Medical School, London, 2012

Biography

Palak completed his PhD in Liver Immunology in 2015, securing a competitively awarded Wellcome Trust Clinical Research Fellowship. During this time, his work on risk stratification in PBC was ranked the highest scoring clinical abstract at the EASL International Liver Congress.

Palak went on to receive the Investigator of the Year award in 2017 for work on gut-liver immunity in PSC, was recipient of the Andy Burroughs’ prize for best Hepatology research at the British Association for Study of the Liver (BASL), and won the Elwyn Elias prize for research into PSC and liver transplantation the same year. Palak is currently a mid-career researcher at the University 麻豆精选, with 50% protected research time and the remainder dedicated to clinical practice.

Palak currently leads the PBC and PSC clinical research programme, with the overarching themes of work focussing on the role of gut-liver immunity, modelling the natural history of PBC and PSC, generating real-world clinical outcome data, and risk stratification pre- and post-transplantation.

Teaching

  • Lead for the year 4 and 5 gastroenterology and hepatology MBChB programme

Postgraduate supervision

Post-doc supervision

  • Dr. Scott Davies
  • Dr. Hannah Crothers

MD/PhD supervision

  • Dr. Nadir Abbas
  • Dr. Sheeba Khan

Research

  • Exercise intervention to attenuate symptoms in cholestasis
  • Epidemiology of primary sclerosing cholangitis
  • Risk stratification in chronic cholestatic liver disease
  • Characterising the natural history of PBC and PSC
  • Gut-liver immunity in the pathogenesis of autoimmune liver disease
  • Clinical trial design in rare disease
  • Immune-therapy induced liver injury
  • Exploring stability and function of regulatory T cells in human livers to develop and deliver immunotherapy for autoimmune hepatitis

Publications

Recent publications

Article

Al-Shakhshir, S, Quraishi, MN, Mullish, B, Patel, A, Vince, A, Rowe, A, Homer, V, Jackson, N, Gyimah, D, Shabir, S, Manzoor, S, Cooney, R, Alrubaiy, L, Quince, C, van Schaik, W, Hares, MF, Beggs, AD, Efstathiou, E, Rimmer, P, Weston, C, Iqbal, T & Trivedi, PJ 2025, '', BMJ open, vol. 15, no. 1, e095392.

Freer, A, Williams, FR, Durman, S, Hayden, J, Armstrong, MJ & Trivedi, PJ 2024, '', JHEP Reports, vol. 6, no. 12, 101210.

UK-PBC audit group, Abbas, N, Smith, R, Flack, S, Bains, V, Aspinall, RJ, Jones, RL, Burke, L, Thorburn, D, Heneghan, M, Yeoman, A, Leithead, J, Braniff, C, Robertson, A, Mitchell, C, Thain, C, Mitchell-Thain, R, Jones, D, Trivedi, PJ, Mells, GF & Alrubaiy, L 2024, '', JHEP Reports, vol. 6, no. 1, 100931.

Global & ERN Rare-Liver PBC Study Groups, Lam, L, Soret, P-A, Lemoinne, S, Hansen, B, Hirschfield, G, Gulamhusein, A, Montano-Loza, AJ, Lytvyak, E, Par茅s, A, Olivas, I, Londono, M-C, Rodr铆guez-Tajes, S, Eaton, JE, Osman, KT, Schramm, C, Sebode, M, Lohse, AW, Dalekos, G, Gatselis, N, Nevens, F, Cazzagon, N, Zago, A, Russo, FP, Floreani, A, Abbas, N, Trivedi, P, Thorburn, D, Saffioti, F, Barkai, L, Roccarina, D, Calvaruso, V, Fichera, A, Delamarre, A, Sobenko, N, Villamil, AM, Medina-Morales, E, Bonder, A, Patwardhan, V, Rigamonti, C, Carbone, M, Invernizzi, P, Cristoferi, L, van der Meer, A, de Veer, R, Zigmond, E, Yehezkel, E, Kremer, AE, Deibel, A, Bruns, T, Gro脽e, K, Wetten, A, Dyson, JK, Jones, D, Levy, C, Tanaka, A, Dumortier, J, Pageaux, G-P, de L茅dinghen, V, Carrat, F, Chazouill猫res, O & Corpechot, C 2024, '', Clinical Gastroenterology and Hepatology.

the OCTAVE Collaborative Group, PITCH study, and the EASL supported COVID-Hep vaccine network, Murray, SM, Pose, E, Wittner, M, Londo帽o, MC, Schaub, G, Cook, J, Dimitriadis, S, Meacham, G, Irwin, S, Lim, Z, Duengelhoef, P, Sterneck, M, Lohse, AW, Perez, V, Trivedi, P, Bhandal, K, Mullish, BH, Manousou, P, Provine, NM, Avitabile, E, Carroll, M, Tipton, T, Healy, S, Burra, P, Klenerman, P, Dunachie, S, Kronsteiner, B, Maciola, AK, Pasqual, G, Hernandez-Gea, V, Garcia-Pagan, JC, Lampertico, P, Iavarone, M, Gines, P, L眉tgehetmann, M, Schulze zur Wiesch, J, Russo, FP, Barnes, E & Marjot, T 2024, '', Journal of Hepatology, vol. 80, no. 1, pp. 109-123.

Roberts, SB, Choi, WJ, Worobetz, L, Vincent, C, Flemming, JA, Cheung, A, Qumosani, K, Swain, M, Grbic, D, Ko, HH, Peltekian, KM, Abrahamyan, L, Saini, M, Tirona, K, Aziz, B, Lytvyak, E, Invernizzi, P, Ponsioen, CY, Bruns, T, Cazzagon, N, Lindor, K, Dalekos, GN, Gatselis, NK, Verhelst, X, Floreani, A, Corpechot, C, Mayo, MJ, Levy, C, Londo帽o, M-C, Battezzati, PM, Pares, A, Nevens, F, van der Meer, A, Kowdley, KV, Trivedi, PJ, Lleo, A, Thorburn, D, Carbone, M, Selzner, N, Gulamhusein, AF, Janssen, HLA, Montano-Loza, AJ, Mason, AL, Hirschfield, GM & Hansen, BE 2024, '', JHEP Reports.

Quraishi, MN, Cheesbrough, J, Rimmer, P, Mullish, BH, Sharma, N, Efstathiou, E, Acharjee, A, Gkoutus, G, Patel, A, Marchesi, JR, Camuzeaux, S, Chappell, K, Valdivia-Garcia, MA, Ferguson, J, Brookes, M, Walmsley, M, Rossiter, A, van Schaik, W, McInnes, RS, Cooney, R, Trauner, M, Beggs, A, Iqbal, T & Trivedi, PJ 2024, '', Journal of Crohn's & Colitis.

Montano-Loza, AJ, Lytvyak, E, Hirschfield, G, Hansen, BE, Ebadi, M, Berney, T, Toso, C, Magini, G, Villamil, A, Nevens, F, Van den Ende, N, Pares, A, Ruiz, P, Terrabuio, D, Trivedi, PJ, Abbas, N, Donato, MF, Yu, L, Landis, C, Dumortier, J, Dyson, JK, van der Meer, AJ, de Veer, R, Pedersen, M, Mayo, M, Manns, MP, Taubert, R, Theresa, K, Belli, LS, Mazzarelli, C, Stirnimann, G, Floreani, A, Cazzagon, N, Russo, FP, Burra, P, Zigmound, U, Houri, I, Carbone, M, Mulinacci, G, Fagiuoli, S, Pratt, DS, Bonder, A, Schiano, TD, Haydel, B, Lohse, A, Schramm, C, R眉ther, D, Casu, S, Verhelst, X, Beretta-Piccoli, BT, Robles, M, Mason, AL, Corpechat, C & Global PBC Study Group 2024, '', Journal of Hepatology.

Hussain, N, Ma, C, Hirschfield, G, Walmsley, M, Hanford, P, Vesterhus, M, Kowdley, K, Bergquist, A, Ponsioen, C, Levy, C, Assis, D, Schramm, C, Bowlus, C, Trauner, M, Aiyegbusi, OL, Jairath, V & Trivedi, PJ 2024, '', BMJ open, vol. 14, no. 6, e080143.

Trivedi, PJ, Arndtz, K, Abbas, N, Telford, A, Young, L, Banerjee, R, Eddowes, P, Jhaveri, KS & Hirschfield, GM 2024, '', Alimentary Pharmacology & Therapeutics, pp. 1-10.

Greenman, R, Segal-Salto, M, Barashi, N, Hay, O, Katav, A, Levi, O, Vaknin, I, Aricha, R, Aharoni, S, Snir, T, Mishalian, I, Olam, D, Amer, J, Salhab, A, Safadi, R, Maor, Y, Trivedi, P, Weston, CJ, Saffioti, F, Hall, A, Pinzani, M, Thorburn, D, Peled, A & Mor, A 2023, '', JCI Insight, vol. 8, no. 12, e162270.

ESOT Guidelines Taskforce 2023, '', Transplant international, vol. 36, 11729.

IAIHG and EASL DHILI Consortium 2023, '', Journal of Hepatology, vol. 79, no. 3, pp. 853-866.

Mayo, MJ, Vierling, JM, Bowlus, CL, Levy, C, Hirschfield, GM, Neff, GW, Galambos, MR, Gordon, SC, Borg, BB, Harrison, SA, Thuluvath, PJ, Goel, A, Shiffman, ML, Swain, MG, Jones, DEJ, Trivedi, P, Kremer, AE, Aspinall, RJ, Sheridan, DA, D枚rffel, Y, Yang, K, Choi, YJ & McWherter, CA 2023, '', Alimentary Pharmacology & Therapeutics.

Review article

Trivedi, PJ, Hirschfield, GM, Adams, DH & Vierling, JM 2024, '', Gastroenterology, vol. 166, no. 6, pp. 995-1019.