Dr Myriam Chimen MSc, PhD

Myriam Chimen

Department of Inflammation and Ageing
Honorary Senior Research Fellow

Contact details

Email
chimenm@bham.ac.uk
Twitter
Address
Department of Inflammation and Ageing
Birmingham University Research Labs
Queen Elizabeth Hospital
Mindelsohn Way
Birmingham
B15 2WB

Myriam Chimen is Royal Society Dorothy Hodgkin Research Fellow since October 2017. Her main interest is to understand how immune regulatory pathways controlling leukocyte trafficking are impaired with ageing and chronic inflammatory diseases. 

Qualifications

  • Royal Society Dorothy Hodgkin fellowship (2017)
  • PhD, University Âé¶¹¾«Ñ¡ (2012)
  • Masters Biochemistry University of Toulouse, France (2008)

Biography

Cardiovascular Research with Professor Ed Rainger, Dr Asif Iqbal and Dr Myriam Chimen

Myriam completed her undergraduate degree in Biochemistry at the University of Toulouse in France. She then completed her Masters in Biochemistry and Molecular Biology at the University of Toulouse where she developed a strong interest in immunology. She decided to move to Birmingham in the laboratory of Dr Parth Narendran and Professor Ed Rainger where she investigated the immune-modulatory effects of adipokines in type 1 diabetes. Myriam completed her PhD in 2012 where she discovered a novel peptide inhibitor of trans-endothelial migration (PEPITEM) and characterised this novel pathway in health and patients with type 1 diabetes.

Myriam has continued her post-doctoral training in Birmingham on the characterisation of the receptor for PEPITEM. She then embarked on her second post-doctoral position in the laboratory of Professor Ed Rainger where she was investigating the role of platelet-monocyte interactions in the pathogenesis of atherosclerosis. Myriam has now started working on her five-year fellowship to investigate how glucocorticoids modulate the PEPITEM pathway in ageing.

Teaching

  • BMedSc
  • MSc

Postgraduate supervision

Myriam is interested in supervising doctoral research students in the following areas:

  • Effect of age on leukocyte migration
  • Glucocorticoids and their involvement in controlling T-cell trafficking

If you are interested in studying any of these subject areas please contact Myriam on the contact details above. For a full list of available Doctoral Research opportunities, please visit our .

Research

Myriam’s research is focused on understanding how immune regulatory pathways are changed with ageing and age-associated chronic inflammatory conditions. In particular, Myriam wishes to investigate how the control of leukocyte trafficking is affected by the chronic, low grade, chronic inflammation (Inflammageing) associated with ageing.

  • Effect of ageing on the PEPITEM pathway
  • Role of glucocorticoids in the regulation of the PEPITEM pathway
  • Effect of ageing on B-cell trafficking

Other activities

Committee membership:

  • UK Cell Adhesion Society (UKCAS
  • BSI Leukocyte Migration Affinity Group
  • PERCAT University Âé¶¹¾«Ñ¡

Conference organisation:

  • Co-organiser of the 2nd ICVS away day conference  (2017)
  • Co-organiser of the 3rd BSI Leukocyte Migration Affinity Meeting - University of Leeds (2017)
  • Co-organiser of the 3rd PERCAT gala- University Âé¶¹¾«Ñ¡ (2016)
  • Co-organiser of the 27th UK Adhesion Society Meeting in Birmingham (2015)
  • Co-organiser of the 26th UK Adhesion Society Meeting in Birmingham (2013)

Publications

Recent publications

Article

Fenton, C, Martin, C, Jones, R, Croft, A, Campos, J, Naylor, A, Taylor, A, Chimen, M, Cooper, M, Lavery, G, Raza, K & Hardy, R 2021, '', Annals of the Rheumatic Diseases, vol. 80, no. 2, pp. 250-260.

Chimen, M, Evryviadou, A, Box, CL, Harrison, MJ, Hazeldine, J, Dib, LH, Kuravi, SJ, Payne, H, Price, JMJ, Kavanagh, D, Iqbal, AJ, Lax, S, Kalia, N, Brill, A, Thomas, SG, Belli, A, Crombie, N, Adams, RA, Evans, S-A, Deckmyn, H, Lord, JM, Harrison, P, Watson, SP, Nash, GB & Rainger, GE 2020, '', Haematologica, vol. 105, no. 5, pp. 1248-1261.

Gilbert, SG, Krautter, F, Cooper, D, Chimen, M, Iqbal, AJ & Spill, F 2020, '', Journal of Physics D: Applied Physics, vol. 53, no. 42, 424002.

Krautter, F, Recio, C, Hussain, MT, Lezama, DR, Maione, F, Chimen, M & Iqbal, AJ 2020, '', Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 130, 110595.

Hopkin, S, Lord, JM & Chimen, M 2020, '', Pharmacological Research.

Hopkin, S, Lewis, J, Krautter, F, Chimen, M & McGettrick, H 2019, '', Frontiers in Pharmacology, vol. 10, 184.

Borgognone, A, Shantsila, E, Worrall, S, Prompunt, E, Loka, T, Loudon, BL, Chimen, M, Rainger, GE, Lord, JM, Turner, A, Nightingale, P, Feelisch, M, Kirchhof, P, Lip, G, Watson, SP, Frenneaux, MP & Madhani, M 2018, '', Cardiovascular Research, vol. 114, pp. 1313–1323.

Harrison, MJ, Chimen, M, Hussain, M, Iqbal, AJ, Senis, Y, Nash, G, Watson, S & Rainger, G 2018, '', Journal of Cellular and Molecular Medicine, vol. 22, no. 9, pp. 4317-4327.

Reyat, J, Chimen, M, Noy, P, Szyroka, J, Rainger, G & Tomlinson, M 2017, '', Journal of Immunology, vol. 199, no. 2, pp. 666-676.

Apta, BHR, Chimen, M & Mcgettrick, HM 2017, '', Methods in molecular biology, vol. 1591, pp. 101-119.

Chapter (peer-reviewed)

Chimen, M, Apta, B & McGettrick, H 2017, . in T-Cell Trafficking: Methods and Protocols. vol. 1591, Methods in Molecular Biology (MIMB), Springer, pp. 73-84.

Other contribution

Hussain, M & Chimen, M 2018, .. <>

Martin, C, Ni Chosgora, A, Chimen, M & McGettrick, H 2018, .. <>

Review article

Nathan, P, Gibbs, JE, Rainger, GE & Chimen, M 2021, '', Frontiers in immunology, vol. 12, 673405.

Pezhman, L, Tahrani, A & Chimen, M 2021, '', Frontiers in cell and developmental biology, vol. 9, 624184.