麻豆精选

• Abilitazione Scientifica Nazionale (ASN) a Professore di I Fascia (Italy), 2023
• Fellow of the Higher Education Academy (FHEA, UK), 2016
• PhD in Molecular Oncology and Endocrinology, University of Naples Federico II (Italy), 2007
• Medical Biotechnology Degree (combined 5 year BSc and MSc programme, 1st class Honours), University of Naples Federico II (Italy), 2002
• Classical Humanities High School Diploma, Virgilio Institute, Lecce (Italy), 1997

Professor Mauro graduated from the University of Naples 鈥淔ederico II鈥� in Italy with a combined 5-year BSc and MSc degree in Medical Biotechnology in 2002 followed by a PhD in Molecular Oncology and Endocrinology in 2007.

• During his PhD (2002-07), he studied the pro-inflammatory and anti-apoptotic response controlled by the NF-kB family of transcription factors. In these studies he discovered novel mechanisms of activation of NF-kB downstream of TNF receptors and upon endoplasmic reticulum stress as well as the contribution of NF-kB activity to thyroid tumourigenesis (, , , , ).
• During his post-doc (2007-11) 鈥� supported in part by a Foundation Fellowship awarded from the Italian Association for Cancer Research 鈥�, he worked both at the University of Chicago in the USA and Imperial College London at the identification of the molecular mechanisms linking inflammation and metabolism in the adaptive immune system and in cancer (, ).
• In 2011, he moved to the William Harvey Research Institute at the Barts and The London School of Medicine and Dentistry at Queen Mary University of London, where he focused on the investigation of the metabolic control of immune cell effector functions and the implications of the metabolic dependence of immune responses in inflammatory conditions. Through this work he obtained a prestigious Intermediate Basic Science Research Fellowship from the British Heart Foundation in 2012 (until 2019) alongside other competitive research grants, and published a number of papers in the field (e.g., , [; ], , ).
• In 2018 he joined the Institute of Inflammation and Ageing at the University 麻豆精选 as a Professorial Research Fellow in Metabolism and Inflammation to lead a group of scientists working on basic and translational aspects of immunometabolism (e.g. 听 [Press Release闭,听 [],听, [Press Release], , Nat Metab in press).
• In 2020, he was promoted to Professor of Metabolism and Inflammation (watch his听).
• In 2022, he was awarded one of four currently live British Heart Foundation Senior Fellowships running in the quinquennium 2023-28 ().
• In 2023-24, he led on a successful bid to the Marie Sklodowska-Curie Actions Doctorate Network call that will focus on UnderstandiNg fraIlty tOwards a future of healthy ageiNg (UNION) and will run in the quadriennium 2025-2029 (Per i lettori italiani: )

Professor Mauro has supervised the following individuals during their MSc, PhD or during their post-doc. The next position of past members of the group is noted in brackets:

If you are interested in studying any of these subject areas please contact Professor Claudio Mauro directly, or for any general doctoral research enquiries, please email mds-gradschool@contacts.bham.ac.uk.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

The research in the Mauro鈥檚 group focuses on the interconnections between metabolic and inflammatory pathways and how systemic and cellular metabolic alterations in diseases with an inflammatory component lead to aberrant immune cell responses, which favour both the establishment and the propagation of inflammation. In particular, they investigate the mechanisms of metabolic control of T cell-mediated immune responses, including migration, differentiation and cytokine production in physiology and under metabolic stress.

• One key area of their research is how small metabolites, like lactate, which accumulates locally in the inflamed tissue or systemically during acute and chronic inflammation, can impact the fate of the immune-inflammatory response via induction of听 intracellular metabolic rewiring with immediate effect on broad range human diseases (Main Outputs: Research Articles - ,听, Nat Metab in press; Review Articles - , , , , , Trends Immunol in press).听
• Another important aspect of their research is how fatty acids can impact the outcomes of an immune response, with repercussions on obesity-related diseases (Main Outputs: Research Articles - , , , New Article under review; Review Articles - ).

Overall, their studies indicate that interfering with metabolic pathways (i.e., lipid, glucose and oxidative metabolism) alters immune cell effector functions and can be exploited for therapy.

Their main research outputs are:

• 84 total publications: h-index=38; i10-index=63; citations=>6,500 ().
• Best research articles:听 (1^st author); (co-author); (1^st, corresponding and lead author); (co-author); (last author); (2^nd last author); Nat Metab in press (last author).
• Best 2^nd tier research articles:听 (co-1^st author); (3^rd author); (2^nd last author; ); (last author); (co-author); (2^nd last and corresponding author); (co-author); (3^rd last author).
• Senior author research articles:听 (last author);听 (2^nd last author); (1^st, corresponding and lead author); (2^nd last and corresponding author); (last author); (last author); (joint last author); (2^nd last author), (last author), Nat Metab in press (last author).
• Best review/commentary articles:听 (last author); (last author); (last author); (last author); 听(2^nd author); (last author); (last author); (last author); Trends Immunol in press (last author).

Professor Mauro research is embedded in the Departments of Inflammation and Ageing, Cardiovascular Sciences听and Metabolism and Systems Sciences, (CMAR), Centre of Membrane Proteins and Receptors (COMPARE), Centre for Neurogenetics Research, and Biomedical Research Centre (BRC) , and Units.

Professor Mauro is also active on engaging the public and the students communities:

• Article in 听 on the links between diet and skin inflammatory diseases
• Article in the on living healthier longer (further discussed here open access)
• Interview with on Inflammageing
• Interview on

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Editorial Board Memberships

External Committee Memberships

• Arthritis Research UK Foundation Fellowships (2019)
• Nutrition-responsiveness of the immune system (NUTRIMMUNE)” international call of the Joint Programming Initiative “a Healthy Diet for a Healthy Life” (JPI HDHL)  (2022)
• Wellcome Trust CDA and Discovery Awards Immunology Panel (2023)
• UKRI Future Leaders Fellowships (2023 - current)

• Versus Arthritis Early Detection and Targeted Treatments, "Discovery" Panel (2024)

Internal Committee Memberships

• REF2021 Committee, Institute of Inflammation and Ageing (Co-Lead - Outputs) and MDS (2020-21)
• BHF Accelerator Award Grant Committee (2020-2023)
• Research Strategy Committee (Co-Lead), Institute of Inflammation and Ageing (2021-2023)
• BHF Strategy Group (current)
• PGR Committee, Department of Inflammation and Ageing (current)
• Research Strategy Committee, Department of Inflammation and Ageing (current)
• Executive Committee, Department of Inflammation and Ageing (current)

Entrepreneurships

• Lmito Therapeutics Scientific Advisory Board Member (current)
• Solute Guard Therapeutics (SGTx) CSO and Founder (launching June/July 2024)