Dr Susanne N. Wijesinghe BSc (Hons) MSc PhD

Dr Susanne Wijesinghe

Department of Inflammation and Ageing
Post-doctoral Researcher

Contact details

Email
s.n.wijesinghe@bham.ac.uk
Twitter
Address
Department of Inflammation and Ageing
Queen Elizabeth Hospital
University 麻豆精选
Edgbaston
Birmingham
B15 2WB

Dr Susanne Wijesinghe has a background in non-coding RNAs, transcriptomics and gene editing in arthritic joints and is developing her interests in exosome biology in cellular crosstalk.

Her current research in Professor Simon Jones’ group focuses on the effects of obesity and pain in the pathology of ageing and diseased joints.

Qualifications

  • PhD in Molecular Biology, University 麻豆精选, 2018
  • MSc in Molecular Biotechnology, University 麻豆精选, 2014
  • BSc (Hons) in Biomedical Sciences, Royal Holloway University of London, 2012

Biography

Sue studied Biomedical Science at Royal Holloway, University of London, before pursuing a master鈥檚 in Molecular Biotechnology at University 麻豆精选, gaining an interest in epigenetics, gene regulation and transcriptomics. She went on to complete her PhD studying long non-coding RNAs during haematopoietic lineage commitment in Dr. Aditi Kanhere鈥檚 lab where she utilized CRISPR/Cas9 technology to silence CCDC26 lncRNA and determine its functional role in cell fate decisions through DNMT1- associated methylation.聽

Sue then moved to the Institute of Inflammation and Ageing where she joined the OA and Musculoskeletal Inflammation Group led by Prof. Simon Jones where she continues to investigate the epigenetic role of non-coding RNAs in the context of osteoarthritis. 聽Here, Sue has developed her research interests on the inflammatory effects of obesity and pain within arthritic joints and through successful collaborations also expanded her interests into the role of exosomes in cellular crosstalk during ageing-associated senescence.

Teaching

Lectures and small group teaching in MPharm: Health, Disease and Therapeutics

Research

  • Understanding the role of adipose tissue and adipose-derived extracellular vesicles in mediating obesity-associated decline in musculoskeletal health with ageing
  • Investigating synovial fibroblast pain pathotypes as a roadmap to understanding and targeting the complexity of patient-reported joint pain in osteoarthritis
  • Utilizing multi-omic technologies to pathotype obesity-associated synovial fibroblasts win the pro-inflammatory joint environment
  • Interrogating extracellular vesicle microRNA cargo from synovial fibroblasts involved in inducing senescence and pro-inflammatory bystander effect
  • Characterising the role of obesity-associated non-coding RNAs during joint inflammation

Publications

Recent publications

Article

Pattison, L, Hickman, R, Hilton, H, Dannawi, M, Wijesinghe, S, Ladds, G, Yang, L, Jones, S & St. John Smith, E 2024, '', Proceedings of the National Academy of Sciences, vol. 121, no. 51, e2410653121.

Acharjee, A, Wijesinghe, S, Russ, D, Gkoutos, G & Jones, S 2024, '', Journal of translational medicine, vol. 22, no. 1, 592.

Wijesinghe, S, Badoume, A, Nanus, D, Sharma-Oates, A, Farah, H, Certo, M, Alnajjar, FAQ, Davis, E, Mauro, C, Lindsay, MA & Jones, S 2023, '', Clinical and Translational Medicine, vol. 13, no. 4, e1232.

Farah, H, Wijesinghe, S, Nicholson, T, Alnajjar, FAQ, Certo, M, Alghamdi, AMA, Davis, E, Young, S, Mauro, C & Jones, S 2022, '', International Journal of Molecular Sciences, vol. 23, no. 6, 3266.

Wijesinghe, SN, Brown, TJ, Nanus, DE, Housmans, B, Green, JA, Hackl, M, Choi, KK, Arkill, KP, Welting, T, James, V, Jones, SW, Peffers, MJ & Anderson, JR 2022, '', Frontiers in Molecular Biosciences, vol. 9, 971621.

UK GAPP Study Group 2021, '', Journal of Thrombosis and Haemostasis, vol. 19, no. 1, pp. 262-268.

Nanus, D, Badoume, A, Wijesinghe, S, Halsey, A, Hurley, P, Ahmed, Z, Botchu, R, Davis, E, Lindsay, MA & Jones, S 2021, '', EBioMedicine, vol. 72, 103618.

Alnajjar, FAQ, Sharma-Oates, A, Wijesinghe, S, Farah, H, Nanus, D, Nicholson, T, Davis, E & Jones, S 2021, '', Cells, vol. 10, no. 4, 786.

Chapter (peer-reviewed)

Wijesinghe, SN, Lindsay, MA & Jones, SW 2022, . in Advances in Experimental Medicine and Biology. vol. 1363, Advances in Experimental Medicine and Biology, Springer, pp. 35-70.

Abstract

Wijesinghe, SN, Acharjee, A, Russ, D, Gkoutos, G & Jones, SW 2024, '', Osteoarthritis and Cartilage, vol. 32, no. Supplement 1, pp. S466-S467.

Wijesinghe, SN, Botchu, R, Sardeli, AV, Ditchfield, CN, Davies, ET & Jones, SW 2024, '', Osteoarthritis and Cartilage, vol. 32, no. Supplement 1, pp. S509-S510.

Nanus, D, Wijesinghe, S, Pearson, M, Hadjicharalambous, MR, Rosser, A, Davis, E, Lindsay, M & Jones, S 2020, '', Arthritis and Rheumatology, vol. 72, no. 4, pp. A16-A16.

Review article

Wijesinghe, S, Ditchfield, C, Flynn, S, Agrawal, J, Davis, E, Dajas-Bailador, F, Chapman, V & Jones, S 2024, '', Osteoarthritis and Cartilage.

Nicholson, TA, Sagmeister, M, Wijesinghe, SN, Farah, H, Hardy, RS & Jones, SW 2023, '', Pharmaceutics, vol. 15, no. 1, 237.

Wijesinghe, S, Lindsay, MA & Jones, S 2021, '', Biomedicines, vol. 9, no. 8, 902.