Dr Christian Ludwig

Christian Ludwig

Department of Metabolism and Systems Science
Associate Professor in Metabolic Biophysics
Lead for Academic Integrity in the Department of Metabolism and Systems Science

Contact details

Email
c.ludwig@bham.ac.uk
Address
University 麻豆精选
Edgbaston
Birmingham
B15 2TT
UK

Funded by the Higher Education Founding Council of England (HEFCE)

Biography

Career History

  • 2015 - Lecturer for Metabolic Biophysics, University 麻豆精选
  • 2008-2015 -Scientific Officer for Biomolecular NMR Spectroscopy, University 麻豆精选
  • 2004-2008 - Computer Systems Architect (HWB-NMR), University 麻豆精选
  • 2001-2004 - Postdoctoral Research Fellow, St. George’s Hospital Medical School, London
  • 2001- PhD (Biochemistry), JWG University Frankfurt
  • 1995- Diploma (Biochemistry), JWB University Frankfurt

Research

Research in Christian's group is focused on the development of novel experimental and analytical approaches to map metabolic pathway activities without necessarily assuming a particular metabolism model for a given cell type with a strong focus on studying metabolism of ex-vivo perfused kidneys.

The primary method the research group uses and is developing is NMR- and GC/MS-based metabolic pathway analysis and tracking stable isotope tracer-based metabolic flux (). These approaches are driving the growth of disease diagnostics through their ability to map and quantitate systems of metabolites which are linked to genetic and proteomic alterations. The approach would is geared to identify new pathways and metabolic responses. Mammalian cells present a diversity of complex metabolic networks that are compartmentalized and governed by poorly understood regulatory processes. Hence it is very difficult to predict the parts of the metabolic pathways that are important.

The research group's approach is based on Combined Analysis of NMR and MS Spectra (CANMS), leading to synergies which allow for the accurate identification of isotopomer distributions from key metabolites that can then be used as input for guiding metabolism simulation.

Group members

PhD Students: Jay Nath; Thomas Smith

Major collaborators

Dan Tennant (University 麻豆精选), Marta Cascante (University of Barcelona), Adrian Harris (University of Oxford), Stefano Tiziani (University of Austen, Texas), Farhat Khanim (University 麻豆精选), Ulrich Günther (University 麻豆精选), Patrick Pollard (University of Edinburgh), (University 麻豆精选)

Publications

Recent publications

Article

Ludwig, C 2025, '', Metabolites, vol. 15, no. 1, 48.

Patel, K, Nath, J, Smith, T, Darius, T, Thakker, A, Dimeloe, S, Inston, N, Ready, A & Ludwig, C 2025, '', Transplantation direct, vol. 11, no. 1, e1736.

Ta, L, Corrigan, S, Tselepis, C, Iqbal, T, Ludwig, C & Horniblow, R 2024, '', Journal of Controlled Release, vol. 375, pp. 495-512.

Cuozzo, F, Viloria, K, Shilleh, AH, Nasteska, D, Frazer-Morris, C, Tong, J, Jiao, Z, Boufersaoui, A, Marzullo, B, Rosoff, DB, Smith, HR, Bonner, C, Kerr-Conte, J, Pattou, F, Nano, R, Piemonti, L, Johnson, PRV, Spiers, R, Roberts, J, Lavery, GG, Clark, A, Ceresa, CDL, Ray, DW, Hodson, L, Davies, AP, Rutter, GA, Oshima, M, Scharfmann, R, Merrins, MJ, Akerman, I, Tennant, DA, Ludwig, C & Hodson, DJ 2024, '', Cell Reports, vol. 43, no. 4, 114047.

Sostare, E, Bowen, TJ, Lawson, TN, Freier, A, Li, X, Lloyd, GR, Najdekr, L, Jankevics, A, Smith, T, Varshavi, D, Ludwig, C, Colbourne, JK, Weber, RJM, Crizer, DM, Auerbach, SS, Bucher, JR & Viant, MR 2024, '', Chemical Research in Toxicology, vol. 37, no. 6, pp. 923鈥�934.

Stanulovi膰, VS, Al Omair, S, Reed, MAC, Roberts, J, Potluri, S, Fulton-Ward, T, Gudgeon, N, Bishop, EL, Roels, J, Perry, TA, Sarkar, S, Pratt, G, Taghon, T, Dimeloe, S, G眉nther, UL, Ludwig, C & Hoogenkamp, M 2024, '', Haematologica.

Ferrante, L, Rajpoot, K, Jeeves, M & Ludwig, C 2023, '', Wellcome Open Research, vol. 7, 262.

Gama-Almeida, MC, Pinto, GDA, Teixeira, L, Hottz, ED, Ivens, P, Ribeiro, H, Garrett, R, Torres, AG, Carneiro, TIA, Barbalho, BDO, Ludwig, C, Struchiner, CJ, Assun莽茫o-Miranda, I, Valente, APC, Bozza, FA, Bozza, PT, dos Santos, GC & El-Bacha, T 2023, '', Metabolites, vol. 13, no. 7, 879.

Darius, T, Vergauwen, M, Maistriaux, L, Evrard, R, Schlegel, A, Mueller, M, O鈥橬eil, D, Southam, A, Aydin, S, Devresse, A, De Meyer, M, Gianello, P, Ludwig, C, Dutkowski, P & Mourad, M 2023, '', Journal of Clinical Medicine, vol. 12, no. 11, 3731.

Szatkowska, R, Furmanek, E, Kierzek, AM, Ludwig, C & Adamczyk, M 2023, '', International Journal of Molecular Sciences, vol. 24, no. 19, 14763.

GENEVA collaborators 2022, '', Obesity Research and Clinical Practice, vol. 16, no. 3, pp. 249-253.

GENEVA collaborators, Singhal, R, Wiggins, T, Pouwels, S, Rajeev, Y, Madhok, B, Hanif, W, Tahrani, AA, Graham, Y, Ludwig, C & Mahawar, K 2022, '', Obesity surgery.

Grech, O, Seneviratne, S, Alimajstorovic, Z, Yiangou, A, Mitchell, J, Smith, T, Mollan, S, Lavery, G, Ludwig, C & Sinclair, A 2022, '', Neurology, vol. 99, no. 6, pp. e1702-e171.

GENEVA collaborators 2022, '', Obesity surgery, vol. 32, no. 7, pp. 1-13.

Singhal, R, Wiggins, T, Super, J, Alqahtani, A, Nadler, EP, Ludwig, C, Tahrani, A & Mahawar, K 2021, '', Pediatric Obesity, vol. 16, no. 12, e12832.