Dr Lina Schiffer PhD

Dr Lina Schiffer

Department of Metabolism and Systems Science
Honorary Senior Research Fellow

Contact details

Telephone
+44 (0)121 414 8705
Email
l.schiffer@bham.ac.uk
Address
University 麻豆精选
Edgbaston
Birmingham
B15 2TT
UK

Lina’s research investigates how steroid hormones are activated and metabolised in the human body and how they impact on human physiology and pathophysiology. After completing her PhD in steroid biochemistry, she joined Professor Arlt’s group at the Department Metabolism and Systems Science (MSS) as a postdoctoral research fellow in 2016 to employ translation ex-vivo approaches to study steroid metabolism in different human tissues.

Qualifications

  • PhD (Dr. rer. nat.), Saarland University, 2016
  • Diploma in Human and Molecular Biology, Saarland University, 2013

Biography

Lina has a diploma in Human and Molecular Biology and completed her PhD at the Institute of Biochemistry at Saarland University (Germany) working on adrenal steroidogenic cytochromes P450 and their drug-metabolising potential. Since 2016, she has worked as a Postdoctoral Research Fellow with Professor Arlt and the Steroid Metabolome Analysis Core at the University 麻豆精选. Lina trained in analytical chemistry and tandem mass spectrometry for quantitative steroid analysis with Professor Brian Keevil at the Univeristy Hospital of South Manchester.

Research

Lina’s current research in Professor Arlt’s group aims to understand the tissue-specific mechanisms of androgen activation and inactivation and their role for the regulation of metabolic health. This work focusses on key metabolic tissues, such as adipose and the liver, with a special interest in the role of androgens for the development of metabolic dysfunction in women with polycystic ovary syndrome. Additionally, Lina develops liquid chromatography tandem with mass spectrometry and ultraperformance convergence chromatography tandem mass spectrometry methods for steroid profiling in experimental and clinical samples. 

Publications

My NCBI-My bibliography:

Original research papers

Barnard, L, Schiffer, L, Du-Toit, RL, Tamblyn, J, Chen, S, Africander, D, Arlt, W, Foster, P & Storbeck, K-H 2021, '', Endocrinology, vol. 162, no. 3, bqaa231. 

Schiffer, L, Bossey, A, Kempegowda, P, Taylor, A, Akerman, I, Scheel-Toellner, D, Storbeck, K-H & Arlt, W 2021, '', European Journal of Endocrinology, vol. 184, no. 3, pp. 353–363. 

Xu, W, Schiffer, L, Qadir, MMF, Zhang, Y, Hawley, J, Mota De Sa, P, Keevil, BG, Wu, H, Arlt, W & Mauvais-Jarvis, F 2020, '', Diabetes. 

Barnard L, Nikolaou N, Louw C, Schiffer L, Gibson H, Gilligan LC, Gangitano E, Snoep J, Arlt W, Tomlinson JW, Storbeck KH. . J Steroid Biochem Mol Biol. 2020 Jul 3:105724. doi: 10.1016/j.jsbmb.2020.105724. Online ahead of print. PMID: 32629108

Bacila I, Adaway J, Hawley J, Mahdi S, Krone R, Patel L, Alvi S, Randell T, Gevers E, Dattani M, Cheetham T, Kyriakou A, Schiffer L, Ryan F, Crowne E, Davies JH, Ahmed SF, Keevil B, Krone N. . J Clin Endocrinol Metab. 2019 Jul 30. pii: jc.2019-00031. doi: 10.1210/jc.2019-000 PMID: 3136132131

Schiffer L, Adaway JE, Arlt W, Keevil BG. ANNALS EXPRESS: . Ann Clin Biochem. 2019 Apr 30:4563219847498. doi: 10.1177/0004563219847498. PMID: 31037957

Schiffer L, Adaway JE, Arlt W, Keevil BG.  Ann Clin Biochem. 2019 Jan;56(1):64-71. doi: 10.1177/0004563218780904. PMID: 29792048

Neunzig J, Milhim M, Schiffer L, Khatri Y, Zapp J, Sánchez-Guijo A, Hartmann MF, Wudy SA, Bernhardt R. . J Steroid Biochem Mol Biol. 2017 Mar;167:182-191. doi: 10.1016/j.jsbmb.2017.01.002. PMID: 28065637

Schiffer L, Müller AR, Hobler A, Brixius-Anderko S, Zapp J, Hannemann F, Bernhardt R. . J Steroid Biochem Mol Biol. 2016 Oct;163:68-76. doi: 10.1016/j.jsbmb.2016.04.004. PMID: 27125452

Schiffer L, Brixius-Anderko S, Hannemann F, Zapp J, Neunzig J, Thevis M, Bernhardt R. . Drug Metab Dispos. 2016 Feb;44(2):227-37. doi: 10.1124/dmd.115.066829. Epub 2015 Dec 9. PMID: 26658226

Brixius-Anderko S, Schiffer L, Hannemann F, Janocha B, Bernhardt R. . Microb Cell Fact. 2015 Sep 15; 14:135. doi: 10.1186/s12934-015-0333-2. PMID: 26374204

Schiffer L, Anderko S, Hobler A, Hannemann F, Kagawa N, Bernhardt R. . Microb Cell Fact. 2015 Feb 25; 14:25. doi: 10.1186/s12934-015-0209-5. PMID: 25880059

Review Articles

Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH.  J Steroid Biochem Mol Biol. 2019 Jul 27:105439. doi: 10.1016/j.jsbmb.2019.105439. PMID: 31362062

Storbeck KH, Schiffer L, Baranowski ES, Chortis V, Prete A, Barnard L, Gilligan LC, Taylor AE, Idkowiak J, Arlt W, Shackleton CHL. . Endocr Rev. 2019 Jul 11. pii: er.2018-00262. doi: 10.1210/er.2018-00262. PMID: 31294783

Schiffer L, Storbeck KH, Arlt W. . Mol Cell Endocrinol. 2018 Apr 15;465:4-26. doi: 10.1016/j.mce.2017.08.016. Epub 2017 Sep 1.  PMID: 28865807

Schiffer L, Kempegowda P, Arlt W, O'Reilly MW. . Eur J Endocrinol. 2017 Sep;177(3):R125-R143. doi: 10.1530/EJE-17-0124. PMID: 28566439

Schiffer L, Anderko S, Hannemann F, Eiden-Plach A, Bernhardt R. . J Steroid Biochem Mol Biol. 2015 Jul;151:38-51. doi: 10.1016/j.jsbmb.2014.10.011. PMID: 25465475

Schiffer L, Arlt W, O’Reilly MW.  . Front Horm Res. Basel, Karger, 2019, vol 53, pp 33–49 doi: 10.1159/000494901