Dr Jennifer Tamblyn MBChB, BMedSci 1st class honours, PhD

Dr Jennifer Tamblyn

Department of Metabolism and Systems Science
Honorary Clinical Lecturer

Contact details

Telephone
+44 7903047015
Email
j.tamblyn@bham.ac.uk
Twitter
Address
IBR Tower, 2nd floor,
University 麻豆精选
Edgbaston
Birmingham,
B15 2TT

Jennifer is an Honorary Clinical Lecturer at Birmingham Women’s & Children’s Hospital. Funded by a Wellbeing of Women Clinical Research Fellowship, Jennifer utilised her PhD to explore vitamin D metabolism in pregnancy, and the potential effects of vitamin D upon immune cell function within the maternal placenta at the University 麻豆精选. To help answer these questions Jennifer utilised a range of novel experimental techniques, including mass spectrometry-based steroid analysis, RNA-sequence analysis, bio-informatic pathway analysis and mathematical modelling. Her central research interests are fetal implantation, early placentation and immune cell function at the materno-fetal interface. Understanding how these processes become dysregulated in women with recurrent failed implantation and aberrant placentation disorders such as recurrent pregnancy loss, subfertility and pre-eclampsia shall help guide future preventative and therapeutic strategies.

Qualifications

  • Clinical Lecturer in Obstetrics and Gynaecology
  •  PhD Research Clin Ex Med (2018)
  • MRCOG Part 1 (2013)
  • MBChB (2011)
  • BMedSci (2009)

Biography

Having successfully attained a Wellbeing of Women Research Training Fellowship Jennifer completed her PhD at the Institute of Metabolism and Systems Research generating unique data on steroid metabolism and immune cell function across human pregnancy. Of particular interest was the transcriptomic response of uterine natural killer cells to vitamin D and immune challenge.

As a Clinical Lecturer in Obstetrics and Gynaecology Jennifer is now working between the University 麻豆精选 and Birmingham Women’s & Children’s Hospital Foundation Trust. Her main research interests surround early implantation, decidualisation and immune cell function at the materno-fetal interface. As research lead for the CHHIP study, Jennifer’s work has maintained a strong translational focus, studying women at high risk of disorders of malplacentation, in particular pre-eclampsia. Moving forward, Jennifer’s hopes her work shall contribute to the Tommy’s pioneering programme of work upon the prevention of recurrent miscarriage and development of potential future therapeutic strategies.

Jennifer is also Academic Lead for the UK Audit and Research Collaborative in Obstetrics and Gynaecology (UKARCOG; 2015) which has established a National trainee network to promote women's health research and deliver high-quality impactful national research projects.  

Teaching

  • University 麻豆精选 5th year medical student teaching – Large and Small group teaching (Aug 2018- present)
  • University 麻豆精选 – BmedSci Small Group Teaching - 2014 – 2017
  • University 麻豆精选– MBChB2 Small Group Teaching – 2012- 2016

Postgraduate supervision

This is a new skill Jennifer shall develop during her Clinical Lectureship.

Research

  • Implantation failure and disorders of maplacentation in human pregnancy
  • Immune cell function and interactions at the materno-fetal interface
  • Steroid metabolism in pregnancy

Research Groups and Centres

Other activities

  • Clinical Registrar at Birmingham Women’s and Children’s Hospital
  • West Midlands Obstetrics and Gynaecology Trainees' Committee
  • Midlands Research Training Collaborative committee member  (December 2017 – present)
  • Core committee UK Audit and Research Collaborative in Obstetrics and Gynaecology (UK-ARCOG)(Sept 2015- present)
  • Gloucestershire squash county captain (2010- present)

Publications

Zuo J, Quinn LL, Tamblyn J, Thomas WA, Feederle R, Delecluse H-J, Hislop AD, Rowe M. The Journal of Virology 2011. 85: 1604-1614.

Tamblyn JA, Morris RK, Cox P, Hargitai B, Kilby MD. 2013;33(11):1102–1104.

Morris RK, Meller CH, Tamblyn JA, Malin GM, Riley RD, Kilby MD, Robson SC, Khan KS. Accepted British Journal of Obstetrics and Gynaecology 2014.

Tamblyn JA, Lissauer DM, Moss PAH, Cox P, Kilby M. Placenta 2013;34(10):846-55.

Tamblyn JA, A. Norton, L. Spurgeon, V. Donovan, A. Bedford Russell, J. Bonnici, K. Perkins, P. Vyas, I. Roberts, and M. D. Kilby. (2015): fetalneonatal-2014.

Fox C, Tamblyn J, Morris R, Kilby M. PFM.04  Arch Dis Child Fetal Neonatal Ed. 2014;99 Suppl 1:A84.

Tamblyn JA, Hewison M, Wagner CL, Bulmer JN, Kilby MD. J Endocrinol. 2015 Mar;224(3):R107-R121.

 Tamblyn JA, Susarla R, Jenkinson C, Jeffery L, Ohizua O, Chun R, Chan S, Kilby M, Hewison M. . Placenta 50, 70-77. 2016 Dec 18. 

Wattar B, Tamblyn JA, Parry-Smith W, Prior M, Van Der Nelson H. On behalf of UK Audit and Research trainee Collaborative in Obstetrics and Gynaecology (UKARCOG). Risk Manag Healthc Policy. 2017; 10: 1–6.

Wattar B, Tamblyn JA. On behalf of UK Audit and Research trainee Collaborative in Obstetrics and Gynaecology(UKARCOG). . European Journal of Obstetrics and Gynecology and Reproductive Biology 2017; 215: 213 – 214

Powell R, Lissauer D, Tamblyn JA, Beggs A, Cox P. . J Immunol. 2017;199(10):3406-3417

Liu NQ, Larner D, Yao Q, Chun R, Zhou R, Tamblyn JA, Wagner C, Hewison M. . J Steroid Biochem Mol Biol. 2018;177:223-230

Tamblyn JA, Jenkinson C, Larner DP, Hewison M, Kilby MD.. Endocr Connect. 2018;7(1):199-210.

Ganguly A, Tamblyn JA, Finn-Sell S, Chan SY, Westwood M, Gupta J, Kilby MD, Gross SR, Hewison M. . J Endocrinol. 2018;236(2):R93-R103

CHL Beentjes, JP Taylor-King, A Bayani, CN Davis, J Dunster, S Jabbari, GR Mirams, MD Kilby, M Hewison, JA Tamblyn. . J Steroid Biochem Mol Biol. 2019 Jun;190:152-160

Bassel H.Al Wattar on Behalf of the AB-FAB study group. . Submitted to European Journal of Obstetrics & Gynecology and Reproductive Biology May 2019

JA Tamblyn, LE Jeffery, R Susarla, DM Lissauer, SL Coort, A Muñoz Garcia, K Knoblich,, AL Fletcher, JN Bulmer, MD Kilby, M Hewison. . Reproduction 2019; 158(2). https://doi.org/10.1530/REP-18-0509