麻豆精选

Postgraduate qualification

• FRCP Edin - 2021 (Royal College of Physicians of Edinburgh)
• PhD - 2011 (University 麻豆精选)
• CCT - 2010
• MRCOG - 2003
• MD - 1999 (Dr MGR Medical University, Chennai, India)

Medical School

• MBBS - 1996 (Dr MGR Medical University, Chennai, India)

Professor Thangaratinam started her research career as a Clinical Research Fellow at Keele University in 2004, and subsequently joined University of Birmingham in 2006 as a Clinical Lecturer in Obstetrics and Gynaecology. In 2011, she was awarded a PhD in ‘’.

After the completion of her clinical and academic training, she was appointed by Queen Mary University of London (QMUL) to the post of Clinical Senior Lecturer in 2011, and was a full professor at QMUL between 2012-2019. She established the research support network, (9 NHS hospitals, 3 Universities) in North and East London to deliver women’s health research, and, the only dedicated and funded Patient and Public Involvement group for Women’s Health in the UK. As R and D Director for Women’s Health at Barts Health NHS Trust until 2019, she was instrumental in integrating research within everyday clinical practice. She was the joint Director of Barts Research Centre for Women’s Health () and undertook cutting-edge research on the problems facing women and children in East London.

She currently leads a portfolio of work in Women’s Health in areas such metabolic disorders in pregnancy (obesity, gestational diabetes), epilepsy, pre-eclampsia, stillbirth, fetal growth, and preterm birth. 

Clinical

She completed her Advanced Training in Specialist Medicine (ATSM) modules in maternal medicine, labour ward management and medical education, and completed her Core Training (CCT) in obstetrics and gynaecology in August 2010 at the Birmingham Women’s Hospital, the largest and busiest tertiary obstetric unit in West Midlands. Her academic work complemented her interest in maternal medicine with projects in pre eclampsia and epilepsy.

She is an Honorary Consultant at Birmingham Women’s and Children’s NHS Foundation Trust.

A significant proportion of Professor Thangaratinam’s work is towards the development, support and supervision of junior researchers and students. She is the co-lead for Obstetrics and Gynaecology NIHR IAT (Integrated Academic Training) posts, and is responsible for NIHR ACF and ACL appointments. She contributes to the BMedSci teaching for Women’s Health module, and overall to the UG teaching. She is the academic lead for Obstetrics and Gynaecology at West Midlands Deanery.

Primary Supervision

Completed

• PhD Pundir J (2016-2022) Interventions to improve fertility outcomes in polycystic ovary syndrome
• PhD A Hamilton (2013-2019) Views of women and healthcare professionals on lifestyle interventions in pregnancy
• PhD B Wattar - (2013-2017) - Improving health outcomes for pregnant women with metabolic risk factors
• PhD J Allotey (2014-2018) Improving the prediction of adverse pregnancy outcomes
• PhD E Rogozinska (2014-2017) Diet and physical activity based interventions for antenatal weight management
• PhD Chiamaka E (2016-2021) Prevention of gestational diabetes and type 2 diabetes in high-risk women
• MD S Sobhy (2015-2017) Risks of maternal and perinatal outcomes in low and middle-income countries (LMIC)
• MD F Cheong-See (2012-2017) - Predictors of adverse maternal and fetal outcomes in high risk pregnancies
• MD Marleen S (2016-2022) Prediction of preterm birth in twin pregnancies
• MSc M D’Amico (2016) - Clinical trials methodology
• MSc R Balaji (2021) – Public Health
• MSc Ansari K (2021-2022) – Covid in pregnancy

In progress

• PhD Coomar D (2020-)..Preventing Gestational Diabetes Mellitus and related complications in mothers and babies
• PhD Bolou A (2017-) Effects of lifestyle interventions to prevent type 2 diabetes after gestational diabetes

Professor Thangaratinam leads several national and international collaborative research networks, and her work has influenced national and international guidelines. She undertakes major collaborative work with teams in Monash University, Melbourne; Amsterdam Medical Centre, Amsterdam; WHO, Geneva; CREP, Argentina; Utrecht Medical Centre, Utrecht; Ramon Y Cajal Hospital, Spain.

Current Grants

Chief Investigator

• MRC Programme grant (2022-2027). £2.1 million. C-safe: Improving maternal and perinatal outcomes through safe and appropriate caesarean sections in low- and middle-income countries

• NIHR Programme grant (2023-2027). £2.7 million. Epi-Safe: Optimising outcomes in pregnant women with epilepsy and their babies: Reducing maternal seizure risks and assessing long-term safety of antiepileptic drugs

• MRC (2021-2023). £405k.Calcium Supplementation to Prevent Pre-eclampsia in Low- and Middle-Income Countries: Individual Participant Data (IPD) meta-analysis, network meta-analysis and economic evaluation

• NHMRC Australia (UK CI) (2020-2022). £114k. Prediction and Prevention of Spontaneous Preterm Birth: An Individual Participant Data Meta-Analysis Comprising of Prognostic and Therapeutic Data

• NHMRC Australia (UK CI) (2019-2024). £40k. HiPP – Centre of Research Excellence in Health in Preconception and Pregnancy: Prevention of Maternal Obesity

• NIHR HTA (2021-2022). £315k. Diet and Physical Activity in Pregnancy to Prevent Gestational Diabetes: Individual Participant Data (IPD) meta-analysis on the differential effects of interventions with economic evaluation

Project Lead

• Midlands Patient Safety Research Centre (2023-2027). £3.7 million (£1.3M Theme). Theme Lead: Maternal health.

• BRC Birmingham (2023-2027). £36 million (£2M Theme). Theme Lead: Women’s metabolic health

• Innovate UK (2022-2025). £2 million. Novel Biomarker Test with Treatment, to Predict and Prevent Miscarriage and Adverse Birth Outcomes in Ethnically Diverse Patient Populations

Co-investigator

• NIHR Efficacy and Mechanism Evaluation (EME): TABLET Trial (Multicentre randomised trial of levothyroxine) £1.4 m (2011-2018)
• NIHR HTA: A randomised trial of mifepristone and misoprostol versus misoprostol alone for management of missed miscarriage (MifeMiso). £1.8 m (2016-2019).

Chair of Independent Trial Steering Committees

• NIHR HTA - Alife2 Anticoagulants for Living Foetuses in women with recurrent miscarriage and inherited thrombophilia: randomised trial
• SOLVE trial: Randomised Controlled Trial of synthetic osmotic dilator for induction of labour

Member of Data Monitoring Committees

• JGHT - AIMS trial: A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery. 3,412 patients in Malawi, Pakistan, Tanzania, and Uganda; NEJM 2019
• MRC joint funders – CRADLE trial: Effect of novel vital sign device on maternal mortality and morbidity in low-income countries. 10 clusters in Africa, India, Haiti (536,223 deliveries)

Research Funding Board membership

• MRC Applied Global health Board (2020-to date) 

• India Alliance DBT Wellcome
• Research for Patient Benefit (RfPB) London (2016-2020)
• Wellbeing of Women, RCOG, London (2017-2019)

Previous Grants

• Barts Charity (2017-2021). £2 million. Barts Research Centre for Women’s Health (BARC). Prevention of GDM (EMMY), Prevention of Type 2 Diabetes after GDM (OMAHA), Time Lapse Imaging for fertility (TILT)

• NHMRC Australia (UK CI) (2020-2022). £114k. Prediction and Prevention of Spontaneous Preterm Birth: An Individual Participant Data Meta-Analysis Comprising of Prognostic and Therapeutic Data.

• NIHR (2020-2021). £224k. Prediction of Fetal Growth Restriction: Individual Participant Data (IPD) Meta-Analysis with Decision Curve Analysis International Prediction of Complications in Pregnancy: (IPPIC-FGR)

• NIHR HTA (2020-2021). £297K. Diet and physical activity in pregnancy to prevent gestational diabetes: Individual Participant Data (IPD) meta-analysis

• NHMRC Australia (UK CI) (2018-2020). £125K. IPPIC preterm birth prediction IPD meta-analysis

• Barts Charity (2014-20). £498K. Effect of Mediterranean diet in preventing pre-eclampsia in women with metabolic risk factors: A randomised controlled trial (ESTEEM)

• NIHR HTA (2014-2018). £510K. Prediction of pre-eclampsia. IPD meta-analysis (IPPIC pre-eclampsia)

• NIHR HTA (2016-2018). £983K. GBS2 study

• NIHR HTA (2013-2015). £250K. Effects of weight management interventions on maternal and fetal outcomes (i-WIP): Individual patient data (IPD) meta-analysis 

Project Lead

• NIHR HTA (2011-2015). £1.8 million. EMPIRE trial (Antiepileptic drug management in Pregnancy)

• NIHR HTA (2010-2016). £780K. Prediction of complications in early onset pre-eclampsia (PREP)

• NIHR HTA (2010-2011). £120K. Interventions to reduce or prevent obesity in pregnant women

Research areas of interest

Metabolic disorders: Obesity, diabetes and polycystic ovary syndrome

Evidence synthesis through NIHR and WHO funded aggregate and Individual Participant Data (IPD) meta-analysis to determine the effects of diet and physical activity in pregnancy. Shakila led the  study, the largest randomised trial on Mediterranean diet in pregnancy to prevent maternal and offspring complications. She is currently leading three pilot/feasibility studies funded by Barts Charity and North Thames Collaborations for Leadership in Applied Health Research (CLAHRC): trial on the effects of myo-inositol to prevent gestational diabetes; prevention of progression to type 2 diabetes in mothers with gestational diabetes with metformin: Optimising health outcomes by using metformin to reduce risk of diabetes after pregnancy (); and with Mediterranean diet for prevention of progression to type 2 diabetes in women with gestational diabetes ().

Maternal and perinatal medicine: Pre-eclampsia, epilepsy, stillbirth, fetal growth, infection

She leads the International Prediction of Complications in Pregnancy (IPPIC) IPD meta-analysis project funded by NIHR HTA and supported by the WHO. The IPPIC collaborative network consists of 73 collaborators from 21 countries, and is the largest global repository of standardised IPD of over three million pregnancies (15 UK, 66 international datasets). She led the Prediction of complications in women with pre-eclampsia (PREP) study funded by NIHR HTA which led to the development of an app that is accurate to predict complications. She led the NIHR HTA funded EMPiRE trial, the first randomised trial involving women with epilepsy. Her work on risk of stillbirth in twin pregnancies (BMJ 2016) garnered significant media attention.

Global Health: Caesarean section, anaemia

Assessment of the safety of caesarean section in Low and Middle Income Countries (LMIC) through large meta-analyses on risks associated with anaesthesia (Lancet Global Health 2016) and the burden of maternal death following caesarean section in LMIC (Lancet 2019). The focus on the effective prevention of anaemia in pregnancy and its complications in women and children with iron fish and also with use of intravenous iron.

From 2020-2024, Professor Thangaratinam is a key member of the Executive Group that supported the Director in developing the vision and strategy of Institute of Metabolism and Systems Research (IMSR), successfully steering the Institute during the challenges of the pandemic, contributing to the VCIR, and making key appointments to leadership positions within the Institute. 

As joint-Director of WHO Collaborating Centre for Global Women’s Health, and academic women’s health lead at , her responsibilities bridge across Institutes and Institutions.

Prior to that, she led the Centre that was established in 2017. She was instrumental in establishing the Katie’s Team, the first fully funded PPIE (Patient and Public Involvement and Engagement) Group dedicated to improving Women’s Health through research. The lay members in the team have co-authored publications, held responsibilities as panel members in NIHR grant funding bodies, and provided input to external teams. At Birmingham, she created a new PPI group for Women in the West Midlands named ‘The Hildas’.

As R and Director of , she leads the R and D strategy development and delivery. Previously, as R and D Director for Women’s Health at (2012-2019), one of the largest number of maternities in Europe, she led the rapid expansion of the department.

Regionally, she established the that brings together early career and established researchers and clinicians, policy makers and key primary care and public health leaders through a dynamic network that focuses on prioritising the care of Women and their newborns through cutting edge research both within Birmingham and across West Midlands.

Nationally, she led the development of the national RCOG Greentop guideline on epilepsy in pregnancy. As a member of the UK Chief Medical Officers’ infographic development group on physical activity in pregnancy, she was involved in making UK wide recommendations.

Globally, she successfully leads 37 research groups on global project, the i-WIP (International Weight Management in Pregnancy), in collaboration with WHO (World Health Organisation). As lead for the Global IPPIC Collaborative Group, she manages a large network of over 60 research teams involved in prediction studies: IPPIC-pre-eclampsia; IPPIC -stillbirth; and IPPIC-preterm birth. As  part of the international guideline committee she developed guidelines for the management of sub fertility in women with polycystic ovary disease. Her work includes major collaborative work with teams in Monash University, Melbourne; Amsterdam Medical Centre, Amsterdam; WHO, Geneva; CREP, Argentina; Utrecht Medical Centre, Utrecht; Ramon Y Cajal Hospital, Spain.